Background Preclinical and proof-of-concept studies suggest a cardioprotective effect of
remote ischemic preconditioning (RIPC). However, two major clinical trials (ERICCA and …

Background Clinical documentation has undergone a change due to the usage of electronic
health records. The core element is to capture clinical findings and document therapy …

Mammalian CYP4B1 enzymes are cytochrome P450 mono-oxygenases that are responsible
for the bioactivation of several exogenous pro-toxins including 4-ipomeanol (4-IPO). In …

Ageing, the progressive functional decline of virtually all tissues, affects numerous living
organisms. Main phenotypic alterations of human skin during the ageing process include …

Within target T lymphocytes, human immunodeficiency virus type I (HIV-1) encounters the
retroviral restriction factor APOBEC3G (apolipoprotein B mRNA-editing enzyme, catalytic …

Although echocardiography is commonly used to analyze cardiac function in small animal
models of cardiac remodeling after myocardial infarction, the different echocardiographic …

Most human pathogenic mutations in 5′ splice sites affect the canonical GT in positions+ 1
and+ 2, leading to noncanonical dinucleotides. On the other hand, noncanonical …

The protein kinase AKT is a central kinase in the heart and has a major impact on
growth/hypertrophy, survival/apoptosis, and metabolism. To gain more insight into AKT …

Aims To examine corneal biomechanics in healthy and keratoconic eyes, with or without
crosslinking obtained by ultrahigh-speed Scheimpflug measurements (Corvis ST). Methods …

A critical step in exon definition is the recognition of a proper splice donor (5΄ ss) by the
5'end of U1 snRNA. In the selection of appropriate 5΄ ss, cis-acting splicing regulatory …