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Outcomes of intravitreal anti-VEGF therapy in eyes with both neovascular age-related macular degeneration and diabetic retinopathy
  1. Francesco Bandello1,
  2. Federico Corvi1,
  3. Carlo La Spina1,
  4. Lucia Benatti1,
  5. Lea Querques1,
  6. Vittorio Capuano2,
  7. Jonathan Naysan3,4,
  8. Xuejing Chen5,
  9. David Sarraf5,6,
  10. Maurizio Battaglia Parodi1,
  11. Eric Souied2,
  12. K Bailey Freund3,4,
  13. Giuseppe Querques1,2
  1. 1Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy
  2. 2Department of Ophthalmology, Hopital Intercommunal de Creteil, University Paris Est Creteil, Cretéil, France
  3. 3Vitreous Retina Macula Consultants of New York, New York, New York, USA
  4. 4Department of Ophthalmology, New York University School of Medicine, New York, New York, USA
  5. 5Department of Ophthalmology, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
  6. 6Greater Los Angeles VA Healthcare Center, Los Angeles, California, USA
  1. Correspondence to Dr Giuseppe Querques, Department of Ophthalmology, University Vita-Salute, Ospedale San Raffaele, Via Olgettina 60, Milan 20132, Italy; giuseppe.querques{at}


Purpose To investigate the outcomes of intravitreal antivascular endothelial growth factor (VEGF) therapy in eyes with both neovascular age-related macular degeneration (AMD) and diabetic retinopathy (DR).

Methods Patients from four high-volume referral centres who presented with neovascular AMD and DR, and received intravitreal anti-VEGF therapy, were included. Data retrieved from medical records and multimodal imaging were analysed.

Results Forty-one eyes of 38 patients (21 male, 17 female; mean age 78±8 years) were enrolled. Median follow-up was 28±19 (12–72) months with a mean of 9.2±7.4 intravitreal anti-VEGF injections per eye were administrated. Best-corrected visual acuity (BCVA) was 0.5±0.3 logMAR; it improved significantly at 1 year (0.3±0.3 logMAR; p=0.02) and returned to baseline values at last follow-up visit (0.6±0.4 logMAR; p=0.26). Mean central macular thickness (CMT) significantly decreased from 408±150 μm to 328±104 μm at 1 year (p=0.021) and to 335±127 μm at last follow-up visit (p=0.032). The baseline severity of DR was graded as mild non-proliferative DR (NPDR) in 21 (51%) eyes, moderate NPDR in 14 (34%), severe NPDR in 4 (10%) and inactive proliferative DR in 2 (5%). At last follow-up visit, one eye graded as moderate NPDR improved to mild, one eye graded as severe NPDR improved to mild and one eye graded as severe NPDR was inactivated due to panretinal photocoagulation.

Conclusions Outcomes analysis of intravitreal anti-VEGF therapy for eyes with both neovascular AMD and DR showed stabilisation of BCVA and reduction of CMT, along with stable or improved DR stage throughout follow-up.

  • Retina
  • Macula
  • Drugs
  • Treatment Medical

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  • Contributors All the authors meet the ICMJE recommendations for authorship credit (substantial contributions to the conception or design of the work, or the acquisition, analysis or interpretation of data; drafting the work or revising it critically for important intellectual content; final approval of the version published; agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved).

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Institutional review board (IRB) approval was obtained for this retrospective study, and the retrospective review of patient information, from all sites. Health Insurance Portability and Accountability Act (HIPPA) compliance was also maintained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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