Article Text

Download PDFPDF
Intraocular pressure elevation and choroidal thinning
  1. Ya Xing Wang1,
  2. Ran Jiang1,
  3. Xiao Lei Ren1,
  4. Jian Dong Chen1,
  5. Hong Li Shi2,
  6. Liang Xu1,
  7. Wen Bin Wei3,
  8. Jost B Jonas1,4
  1. 1Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China
  2. 2College of Biomedical Engineering, Capital Medical University, Beijing, China
  3. 3Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, China
  4. 4Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Seegartenklinik Heidelberg, Germany
  1. Correspondence to Dr Ya Xing Wang and Dr Jost B Jonas, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chong Wen Men, Beijing 100005, China; yaxingw{at}


Purpose To evaluate changes in subfoveal choroidal thickness (SFCT) and peripapillary choroidal thickness (PPCT) after acute intraocular pressure (IOP) elevation provoked by a dark room prone provocative test (DRPPT).

Methods The prospective cohort study included 114 eyes from 65 individuals who had an IOP elevation ≥2 mm Hg during the DRPPT. The participants stayed in a dark room for 2 h with the forehead placed on a desk. At baseline and within 5 min after the end of the DRPPT, tonometry and enhanced depth imaging by spectral-domain optical coherence tomography were carried out.

Results During the DRPPT, IOP increased by 10.1±10.9 mm Hg, SFCT decreased significantly (p<0.001) from 280±80 µm to 267±76 µm and PPCT decreased significantly (p<0.001) from 177±74 to 169±70 µm. In multivariate analysis, a more marked SFCT thinning was associated with higher IOP increase (p<0.001) and shallower anterior chamber depth at baseline (p=0.01). In a similar manner, a higher PPCT change was correlated with a higher IOP increase (p<0.001), and a thicker choroidal thickness at baseline (p<0.001).

Conclusions Choroidal thickness in the subfoveal region and in the peripapillary region decreased parallel to an acute increase in IOP in individuals 2 h after a dark room test. Choroidal thickness depends on the actual IOP, which may be noted when choroidal thickness is measured.

  • Choroid
  • Glaucoma
  • Imaging
  • Intraocular pressure

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Contributors YXW: design, application and manuscript drafting; RJ: study application, measurement; XLR: study application; JDC: study application; HLS: image analysis; LX: design, patient collection; WBW: patient collection, statistics; JBJ: study design, manuscript drafting.

  • Funding This work was supported by (National Natural Science Foundation of China) grant number (81570835).

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Ethical Review Committee of Beijing Tongren Hospital.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Linked Articles

  • At a glance
    Keith Barton James Chodosh Jost Jonas