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The efficacy of lens removal plus IOL implantation for the treatment of spherophakia with secondary glaucoma
  1. Jin Yang1,2,
  2. Qi Fan1,2,
  3. Junyi Chen1,2,
  4. Anjian Wang1,2,
  5. Lei Cai1,2,
  6. Hui Sheng1,2,
  7. Wenyi Lu1,2,
  8. Yongxiang Jiang1,2,
  9. Yi Lu1,2
  1. 1Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai, China
  2. 2Myopia Key Laboratory of Health PR China, Shanghai, China
  1. Correspondence to Professor Yi Lu, Department of Ophthalmology, Eye and Ear, Nose, and Throat Hospital of Fudan University, 83 Fenyang Road, Shanghai, Shanghai 200031, China; luyiox{at}


Aims To evaluate the efficacy of lens removal plus intraocular lens (IOL) implantation for spherophakia with secondary glaucoma.

Methods A series of 19 patients (n=24 eyes) were split into two groups according to the degree of zonular abnormality as follows: group 1 (within the range of one quadrant, n=7 eyes) and group 2 (beyond the range of one quadrant, n=17 eyes). The patients in group 1 underwent phacoemulsification+capsular tension ring (CTR)+IOL, whereas patients in group 2 underwent pars plana lensectomy with scleral-fixated posterior chamber (PC) IOL implantation. The best corrected visual acuity (BCVA) (logMAR unit) and intraocular pressure (IOP) were documented at presentation and at 1 day, 7 days, 3 months, 1 year and 3 years postoperatively.

Results The IOP in both groups significantly decreased after surgery (group 1:28.84±5.36 mm Hg at presentation, 15.86±0.79 mm Hg at the 3-year visit, t=6.34, p=0.000; group 2:26.18±12.16 mm Hg at presentation, 14.54±3.40 mm Hg at the 3-year visit, t=3.80, p=0.01). The BCVA increased from 0.79±0.36 at baseline to 0.44±0.38 at the 3-year follow-up but did not reach a significantly different level in group 1 (t=1.72, p=0.11), whereas the BCVA significantly increased from 1.15±0.75 at baseline to 0.43±0.38 at the 3-year visit in group 2 (t=3.45, p=0.02).

Conclusions Both phacoemulsification+CTR+IOL and lensectomy with scleral-fixated PC IOL implantation are effective in lowering the IOP and enhancing the visual acuity in patients with spherophakia and secondary glaucoma.

  • Glaucoma
  • Lens and zonules
  • Treatment Surgery

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