Article Text

Download PDFPDF
Clinical and demographic study of microsporidial keratoconjunctivitis in South India: a 3-year study (2013–2015)
  1. Rohan Agashe1,
  2. Naveen Radhakrishnan1,
  3. Sayali Pradhan1,
  4. Muthiah Srinivasan1,
  5. Venkatesh N Prajna1,
  6. Prajna Lalitha2
  1. 1Department of Cornea and Refractive Services, Aravind Eye Hospital, Madurai, Tamil Nadu, India
  2. 2Department of Ocular Microbiology, Aravind Eye Hospital, Madurai, Tamil Nadu, India
  1. Correspondence to Dr Prajna Lalitha, Department of Ocular Microbiology, Aravind Eye Hospital, 1, Anna Nagar, Madurai 625020, Tamil Nadu, India; lalitha{at}


Aim To study the demographic profile, clinical features, treatment outcome and ocular morbidity of smear-positive microsporidial keratoconjunctivitis.

Methods Retrospective case series of all patients with clinical features of microsporidial keratoconjunctivitis and who were smear positive for the same on Gram stain from January 2013 to December 2015. Demographic data, predisposing factors, microbiological investigations, clinical course and visual outcome were analysed.

Results Of the 10 655 patients with conjunctivitis, 550 (5.2%) patients were positive for microsporidia on Gram stain during this time period. The disease was prevalent throughout the year with an increased incidence from July to December. Bilateral involvement was seen in 27 (4.9%) patients. There was no predisposing risk factor in 428 (77.8%) patients. 384 (69.1%) patients had received prior treatment before presentation to us with the most common drug being antibiotic in 285 (49.4%) patients. All the patients underwent diagnostic corneal debridement and received topical 0.3% fluconazole eye drops four times a day. Of the 296 patients who followed-up, 187 (63.1%) patients had complete resolution without sequelae. 68 (22.9%) had persistent superficial punctate keratopathy, 30 (10.1%) developed subepithelial nummular keratitis. No significant change in visual acuity was seen in 255 (80.7%) eyes, two or more line improvement was seen in 48 (15.2%) eyes, while two or more line worsening was seen in 13 (4.1%) eyes.

Conclusions Microsporidial keratoconjunctivitis is prevalent in South India throughout the year. The characteristic clinical signs and simple microbiological investigation help us to differentiate it from adenoviral keratoconjunctivitis. The visual prognosis is good.

  • Cornea
  • Infection
  • Treatment Medical
  • Microbiology

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Contributors Conception or design of the work; or the acquisition, analysis or interpretation of data for the work—RA, NR, SP, MS, NVP, PL. Drafting the work or revising it critically for important intellectual content—RA, NR, SP, MS, NVP, PL. Final approval of the version to be published—RA, NR, SP, MS, NVP, PL. Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved—RA, NR, SP, MS, NVP, PL.

  • Competing interests None declared.

  • Ethics approval Institutional Review Board, Aravind Eye Hospital, Madurai.

  • Provenance and peer review Not commissioned; externally peer reviewed.