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Factors influencing intraocular pressure, corneal thickness and corneal biomechanics after congenital cataract surgery
  1. Amir Faramarzi,
  2. Sepehr Feizi,
  3. Ali Maghsoodlou
  1. Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  1. Correspondence to Amir Faramarzi, Ophthalmic Research Center, Ophthalmology Department, Labbafinejad Medical Center Pasdaran Ave. Boostan 9 St, Tehran 1666694516, Iran; amirfaramarzy{at}


Aims This study aims to compare intraocular pressure (IOP), central corneal thickness (CCT) and corneal biomechanics among patients with aphakia, patients with primary and secondary pseudophakia and matched controls following congenital cataract surgery and to investigate the factors influencing these variables.

Methods This study included 36 aphakic eyes, 47 primary pseudophakic eyes and 30 secondary pseudophakic eyes. Thirty-four normal eyes of matched volunteers were recruited for comparisons. Postoperative IOP measured with a Goldmann applanation tonometer (IOPGAT), CCT, corneal hysteresis (CH), corneal resistance factor (CRF) and cornea-compensated IOP (IOPCC) were compared among the groups. Univariate analyses and multiple linear regression analyses were used to investigate the influences of independent factors on IOPGAT, CCT, CH, CRF and IOPCC, considering all the operated eyes as one group.

Results IOPGAT was 12.5±0.92, 14.7±1.9, 13.4±2.3 and 15.7±2.0 mm Hg in normal, aphakic, primary pseudophakic and secondary pseudophakic eyes, respectively (p<0.001). CCT was 559.5±42.7, 628.0±61.7, 566.8±35.3 and 585.2±41.1 µm, respectively (p<0.001). CH was 10.87±2.47, 10.42±2.20, 11.84±2.13 and 9.74±1.94 mm Hg, respectively (p=0.019). IOPCC was 15.91±3.74, 18.40±4.35, 14.58±4.36 and 19.05±4.54 mm Hg, respectively (p<0.001). There was no significant difference in CRF among the groups (p=0.06). Regression analyses revealed that the type of operation was significantly associated with IOPGAT (p=0.04), CCT (p<0.001) and CH (p=0.006).

Conclusions IOPGAT, CCT, CH and IOPCC were significantly different in treated eyes compared with normal eyes after congenital cataract surgery. These variables were primarily affected by the type of surgery. Primary intraocular lens implantation preserved corneal structure and function of the anterior chamber angle.

  • congenital cataract surgery
  • intraocular pressure
  • central corneal thickness
  • and corneal biomechanics

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  • Contributors Conception and design: AF, SF. Data acquisition: AM. Data analysis/interpretation: SF. Manuscript preparation: AF, SF. Manuscript critical revision/approval of final version: all authors. All authors agree to be accountable for all aspects of the work and will ensure that any questions that may arise related to the accuracy or integrity of any part of the work will be appropriately investigated and resolved.

  • Competing interests None declared.

  • Ethics approval The present study followed the tenets of the Declaration of Helsinki and was approved by the Ethics Committee of the Ophthalmic Research Centre, which is affiliated with Shahid Beheshti University of Medical Sciences, Tehran, Iran.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Correction notice This article has been corrected since it was published Online First. The p value ’p=0.06' has been added to the Abstract in the sentence “There was no significant difference in CRF among the groups (p=0.06).”

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