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Indocyanine-green-guided targeted laser photocoagulation of capillary macroaneurysms in macular oedema: a pilot study
  1. Michel Paques1,
  2. Elise Philippakis2,
  3. Clémence Bonnet1,
  4. Sabrina Falah1,
  5. Sarah Ayello-Scheer1,
  6. Stéphanie Zwillinger1,
  7. Jean-François Girmens1,
  8. Benedicte Dupas2
  1. 1CHNO des Quinze-Vingts, DHU Sight Restore, INSERM-DHOS CIC, Paris, France
  2. 2Ophthalmology Department, Hôpital Lariboisière, Université Paris 7, Paris, France
  1. Correspondence to Dr Michel Paques, Clinical Investigation Center 1423, Quinze-Vingts Hospital, 28 rue de Charenton, Paris 7512, France; michel.paques{at}


Aims In longstanding diabetic macular oedema (DME) or retinal vein occlusion (RVO), capillary macroaneurysms may develop. Indocyanine green angiography (ICGA) has been shown to optimise their detection. Here, we report the anatomical and functional outcome of the elective photocoagulation of capillary macroaneurysms.

Methods A retrospective, interventional, two-centre study. In eyes with chronic macular oedema and severe hard exsudates due to diabetic retinopathy or RVO, the presence of capillary macroaneurysms (defined by a diameter larger than 150 µm) was assessed by ICGA and optical coherence tomography (OCT). Capillary macroaneurysms were selectively photocoagulated, the presence of photothrombosis within the lumen being assessed by immediate OCT.

Results Four eyes from three patients with DME and five eyes from five patients with RVO were included. The median duration of visual loss was 4 years. Median initial visual acuity (VA) was 20/200. The median number of capillary macroaneurysms per eye was 2 (range, 1–8) and their median size was 410 µm (range, 154–603). Six months after photocoagulation, there was a significant reduction in macular thickness (mean±SD, 528 µm±200 vs 271 µm±152, p<0.05) and improvement of VA (mean log MAR, 0.82 vs 0.58, p<0.05).

Conclusions During macular oedema with severe hard exsudates due to DME or RVO, systematic detection of capillary macroaneurysms by ICGA followed by their OCT-controlled photocoagulation may be of interest. These results may contribute to re-evaluate the role of photocoagulation in the management of longstanding macular oedema.

  • Macula
  • Imaging
  • Treatment Lasers

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  • Contributors MP designed the study and wrote the first draft of the manuscript. BD participated to patient management, study design and contributed to manuscript redaction. J-FG managed patients and participated to study design. EP, CB, SF, SA-S, SZ treated patients and contributed to manuscript redaction.

  • Funding Supported by the Institut National de la Santé et de la Recherche Médicale (Contrat d'Interface 2011), the Agence Nationale de la Recherche (ANR-14-CE17-0011-01) and the Association Contre l'OVR (

  • Competing interests None declared.

  • Ethics approval Société Française d'Ophthalmologie.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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