Objective Inequalities in cataract blindness are well known, but data are rarely disaggregated to explore the combined effects of a range of axes describing social disadvantage. We examined inequalities in cataract blindness and services at the intersection of three social axes.
Methods Three dichotomous social variables (sex (male/female); place of residence (urban/rural); literacy (literate/illiterate)) from cross-sectional national blindness surveys in Pakistan (2001–2004; n=16 507) and Nigeria (2005–2007; n=13 591) were used to construct eight subgroups, with disadvantaged subgroups selected a priori (ie, women, rural dwellers, illiterate). In each data set, the social distribution of cataract blindness, cataract surgical coverage (CSC) and effective cataract surgical coverage (eCSC) were examined. Inequalities were assessed comparing the best-off and worst-off subgroups using rate differences and rate ratios (RRs). Logistic regression was used to assess cumulative effects of multiple disadvantage.
Results Disadvantaged subgroups experienced higher prevalence of cataract blindness, lower CSC and lower eCSC in both countries. A social gradient was present for CSC and eCSC, with coverage increasing as social position improved. Relative inequality in eCSC was approximately twice as high as CSC (Pakistan: eCSC RR 2.7 vs CSC RR 1.3; Nigeria: eCSC RR 8.7 vs CSC RR 4.1). Cumulative disadvantage was observed for all outcomes, deteriorating further with each additional axis along which disadvantage was experienced.
Conclusions Each outcome tended to be worse with the addition of each layer of social disadvantage. Illiterate, rural women fared worst in both settings. Moving beyond unidimensional analyses of social position identified subgroups in most need; this permits a more nuanced response to addressing the inequitable distribution of cataract blindness.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Cataract is the leading cause of blindness globally.1 Reducing cataract blindness is a priority in the Universal Eye Health: a Global Action Plan 2014–20192 (hereafter called the UEH Action Plan) endorsed at the 66th World Health Assembly in 2013. The UEH Action Plan aligns with the broader Universal Health Coverage (UHC) initiative and recognises the importance of promoting equity to achieve universal eye health (UEH). Assessing progress towards health equity necessitates monitoring inequality (ie, the measurable differences between subgroups).3
Cataract blindness and services are unequally distributed across countries and regions, with higher rates of cataract blindness and worse cataract service indicators in poorer and less developed settings.1 ,4 Within countries, women generally5 ,6 —but not always7 —are more likely to be cataract blind than men, with lower access to and use of cataract surgical services. Data to monitor inequalities beyond gender are not routinely collected and reported.
A small number of surveys have analysed cataract outcomes for associations with social variables such as place of residence (urban/rural) and education level and/or literacy, usually as independent risk factors in multivariable logistic regression models.8–10 However, because individuals are not unidimensional (ie, male or female, and separately, literate or illiterate, urban or rural), the multivariable approach typically fails to capture the experience of specific subgroups. Little insight is typically available for the groups ‘in the middle’ such as illiterate men or literate women, and removes the opportunity to understand how social factors interact with one another to increase vulnerability in the most disadvantaged.11
This study aimed to assess inequality in cataract blindness and cataract services at the intersection of three social variables using data from national surveys in Pakistan and Nigeria.
Data from nationwide representative surveys in Pakistan and Nigeria were selected for analysis as they are among the largest blindness surveys undertaken, collected data on a wide range of social variables and used comparable methods.12 ,13 Participant characteristics and previously reported cataract outcomes from these surveys are summarised in table 1.
The three outcome variables examined were cataract blindness, cataract surgical coverage (CSC) and effective cataract surgical coverage (eCSC).
CSC measures the number of people in a defined population with operated cataract as a proportion of those having operable plus operated cataract. In this study, ‘operable cataract’ was defined as cataract causing blindness (ie, presenting VA worse than 3/60). CSC was calculated using the formula [(x+y)/(x+y+z)]×100, where x is individuals with unilateral pseudo/aphakia (ie, operated cataract) and operable cataract in the other eye; y is individuals with bilateral pseudo/aphakia and z is individuals with bilateral operable cataract.8 ,15
eCSC measures the number of people in a defined population with operated cataract and a good outcome (ie, presenting VA 6/18 or better) as a proportion of those having operable plus operated cataract. eCSC was calculated using the formula [(a+b)/(x+y+z)]×100, where a represents individuals with unilateral pseudo/aphakia achieving presenting VA of 6/18 or better in the operated eye and operable cataract in the other eye; b describes individuals with bilateral pseudo/aphakia achieving presenting VA of 6/18 or better in at least one eye; and x, y and z are the same as for CSC.
The social variables used, hereafter described as ‘axes’, were (1) sex (male or female), (2) literacy (literate (read and write easily) or illiterate (read or write with difficulty or not at all)) and (3) place of residence (urban or rural (the latter defined as a settlement with a population of <20 000)). Eight subgroups were generated in each data set by combining these axes (table 2). The subgroups selected a priori as more advantaged on each of the axes were males, literate individuals and urban dwellers.
Analyses were conducted using STATA V.12.0 (StataCorp, College Station, Texas, USA).
The social distribution of cataract indicators was examined by calculating cataract blindness prevalence, CSC, eCSC and their 95% CIs for each subgroup listed in table 2, and constructing graphs for each outcome.
The WHO recommends rate differences (RDs) and rate ratios (RRs) as simple measures to monitor health inequality.17 We selected the most advantaged subgroup as the reference group for calculations (ie, literate, urban males, table 2). RDs (rate in best-off subgroup minus rate in worst-off subgroup) and RRs (rate in best-off subgroup/rate in worst-off subgroup) were calculated for CSC and eCSC. A positive value for RD and RR>1 indicates worse health in the disadvantaged. The more RD diverges from zero and RR diverges from one, the greater the inequality. Conversely, a negative value for RD and RR<1 indicates worse health in the subgroups that were assumed to be advantaged.
To examine the cumulative effect of multiple disadvantage, literacy status and place of residence were added to sex in turn, and the increased odds of higher cataract blindness, and lower CSC and eCSC in the worst-off compared with best-off subgroup was calculated using multiple logistic regression. Nine models were constructed in each country—one for each of the three outcomes (cataract blindness, CSC, eCSC) for three-axis combinations. The assumed best-off subgroup (shown by * in table 2) was used as the reference group, and age was forced into the model. For each outcome, age-adjusted ORs and 95% CI were plotted comparing (1) men and women; (2) literate men and illiterate women; and (3) urban, literate men and rural, illiterate women. Goodness of fit was assessed using the χ2 test.
Social distribution of cataract indicators
The social distribution of cataract blindness was similar in both countries, with illiterate women and men having a higher prevalence than their literate counterparts. Within literacy subgroups, rural dwellers had a higher prevalence than urban dwellers (figure 1). Literate urban dwellers had the lowest prevalence in both countries: in Pakistan literate, urban men (0.1%, 95% CI 0 to 0.5) and in Nigeria literate, urban women (0.4%, 95% CI 0 to 0.9). Conversely, illiterate, rural men in Pakistan (2.7%, 95% CI 2.2 to 3.3) and illiterate, rural women in Nigeria (2.9%, 95% CI 2.4 to 3.3) had the highest prevalence of cataract blindness.
In Pakistan, despite two subgroups of men having the highest prevalence of cataract blindness (2.7% (95% CI 2.2 to 3.3) in illiterate, rural men and 2.4% (95% CI 1.5 to 3.5) in illiterate, urban men compared with 2.2% in both of the corresponding subgroups of women (95% CI 1.8 to 2.6 and 1.6 to 2.9, respectively)), the overall prevalence was lower in men (1.6%, 95% CI 1.3 to 1.9) compared with women (1.9%, 95% CI 1.7 to 2.2). This is due to the higher level of social disadvantage experienced by women—the two most disadvantaged subgroups of men comprised 25% of the sample, whereas the corresponding subgroups of women comprised 45% of the sample (figure 1). In Nigeria, the proportion of women in the two most disadvantaged subgroups (39%) was more than twice that of men (17%), leading to an even greater difference in overall prevalence between women (2.2%, 95% CI 1.9 to 2.6) and men (1.3%, 95% CI 1.0 to 1.6) (figure 1).
Cataract surgical coverage and effective cataract surgical coverage
A social gradient was observed among women and men for CSC and eCSC, with coverage increasing as social position improved, being lowest for illiterate rural dwellers and highest for literate urban dwellers (figure 2). The slope of the gradient was steeper for men than women in Pakistan, whereas in Nigeria the opposite was observed, with greater differences among women than men. In Pakistan, inequality in eCSC was approximately twice as high as inequality in CSC in both absolute and relative terms—absolute inequality (RD) was 21.6% for CSC and 45.9% for eCSC, and relative inequality (RR) was 1.3 (95% CI 0.9 to 1.8) for CSC and 2.7 (95% CI 1.8 to 4.0) for eCSC. In Nigeria, relative inequality in eCSC (RR=8.7) was also around twice as high compared with CSC (RR=4.1). In absolute terms, inequality in eCSC (RD=44.2%) was lower than for CSC (RD=64.6%), partly due to much lower rates of eCSC.
Cumulative disadvantage was evident for all outcomes, with increasing odds of higher cataract blindness prevalence, lower CSC and lower eCSC with the addition of each axis of disadvantage (figure 3). The findings were similar in both countries.
The UEH Action Plan states that ‘all people should have equitable access to health care and opportunities to achieve or recover the highest attainable standard of health, regardless of age, gender or social position’,2 closely aligning with UHC aims.18 Our results show that at the time these surveys were completed there was much to be done to achieve UEH in Pakistan and Nigeria. Despite differences in sociocultural and health system contexts, both countries had large numbers of people blind from cataract (table 1), with a disproportionate number being in disadvantaged social groups (figure 1). The most disadvantaged groups also had lower CSC (figure 2), most likely due to barriers to accessing services not experienced by their more advantaged counterparts. Among those who accessed surgery, the disadvantaged were less likely to have good visual outcomes than the more advantaged (eCSC, figure 2). The larger inequality observed in eCSC compared with CSC highlights the compounding disadvantages of poorer access and worse quality for those already socially disadvantaged. This phenomenon was described decades ago as the inverse care law—those most disadvantaged and in greatest need typically have least access to good quality services.19 The cumulative disadvantage evident in both settings for all outcomes (figure 3) suggests more comprehensive and equity-focused approaches are required to reduce inequalities and achieve the aim of UEH.
Some unpredicted insights also emerged. Men were not uniformly better off than women and certain subgroups of men in Pakistan (illiterate rural and urban dwellers) experienced the worst levels of cataract blindness (figure 1), while more socially advantaged women (literate urban dwellers) fared better than disadvantaged men in all outcomes (figures 1 and 2). Indeed, in Nigeria, literate, urban women fared best in all three outcomes. Such differences highlight the benefit of exploring social axes beyond gender, as well as emphasising the more nuanced picture that emerges beyond the standard multivariate ‘risk factor’ analysis, which previously identified associations between female sex and cataract blindness and CSC in both settings (table 1).8 ,14–16
Moving beyond unidimensional analysis of social position was an approach included in the Equity-Focused Health Research Agenda developed by a WHO Task Force on Research Priorities.20 ,21 We believe this is the first example of such an approach in eye health. The enhanced value of more finely grained information on inequalities, as presented here, is that it provides evidence of specific forms of disadvantage, throws up new questions for research and facilitates the targeting of interventions to those who have the potential to benefit most.11 ,22
Our analysis must be interpreted in relation to several potential limitations. First, the surveys upon which these analyses were based were completed several years ago and should not be interpreted as representing the current situation in these countries. The data are nevertheless illustrative, may well hold true in the countries studied as well as many others and provide a baseline to assess future inequalities in these countries. Furthermore, this study demonstrates the types of analyses that are likely to be of value in blindness surveys in the pursuit of UEH.
Second, despite the fact that these surveys are among the largest eye surveys undertaken in low- and middle-income countries, the size of some subgroups was small, resulting in large 95% CIs around the estimates. Finally, a hierarchical socioeconomic variable from which to construct wealth quintiles was not collected in the surveys, so commonly used inequality measures could not be calculated and we had to rely on simple measures (RD and RR). Despite this, inequalities were evident across the social axes explored, reinforcing the need to undertake more finely grained analyses to identify the subgroups of the population with the greatest needs along with potential to benefit from service improvements.21
There is also much that could be learnt from positive outcomes. For example, how did Pakistan achieve near universal CSC for the most advantaged men, and has this been sustained? Furthermore, how can the quality of cataract surgery be improved for everyone while also extending, accelerating and prioritising good quality services to those most disadvantaged?
The promotion of UEH is an important contributor to achieving UHC. For UEH to be achieved, the prevalence of cataract blindness must be reduced, as well as its unequal distribution addressed. Importantly, cataract blindness can be ameliorated at relatively low cost and with substantial benefits to individuals and societies.23 More evidence on how and with whom to intervene is required if we are to reduce unfair and unacceptable gaps that arise from social and economic disadvantage.24 The analysis approach presented here contributes to filling the evidence gap by identifying the nature and extent of inequalities within populations. Such evidence provides insights into how best to design and evaluate scalable interventions and should help inform policymaking.25 It is now up to societal, health and research leadership to identify and prioritise those most disadvantaged and to make available to them opportunities to access interventions that may transform their lives, thus demonstrating real commitment to ‘leave no one behind’.
The authors thank the survey teams in Pakistan and Nigeria, and those responsible for technical and logistical support, particularly staff in Sightsavers International country offices.
Twitter Follow Anthony Zwi @HEARDatUNSW
Contributors JR conceived and designed the study, contributed to data analysis, and drafted and revised the manuscript. She is guarantor. ABZ interpreted the data, and drafted and revised the manuscript. ACL designed the study, analysed the data and revised the manuscript. IB interpreted the data and revised the manuscript. CEG conceived and designed the study, interpreted the data and revised the manuscript. All authors approve the submission and agree to be accountable for the work.
Funding Funders of the initial survey in Pakistan were Sightsavers, CBM, Fred Hollows Foundation, Pakistan Office of the WHO, Ministry of Health. In Nigeria, the original survey was funded by Sightsavers, Velux Stiftung, CBM and Ministry of Health. Those funders had no role in the analyses presented here.
Competing interests None declared.
Ethics approval Ethical approval for the surveys was granted prior to original collection by the relevant entities in each country. For the analyses presented here, approval was obtained from the London School of Hygiene & Tropical Medicine Ethics Committee (reference 6248).
Provenance and peer review Not commissioned; externally peer reviewed.