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Transcutaneous periorbital electrical stimulation in the treatment of dry eye
  1. Emilio Pedrotti1,
  2. Francesca Bosello1,
  3. Adriano Fasolo1,2,
  4. Anna C Frigo3,
  5. Ivan Marchesoni1,
  6. Alfredo Ruggeri4,
  7. Giorgio Marchini1
  1. 1Department of Neurosciences, Biomedicine, and Movement Sciences, Eye Clinic, AOUI—University of Verona, Verona, Italy
  2. 2Fondazione Banca degli Occhi del Veneto (The Veneto Eye Bank Foundation), Venezia Zelarino, Italy
  3. 3Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy
  4. 4Department of Information Engineering, University of Padova, Padova, Italy
  1. Correspondence to Dr Emilio Pedrotti, Eye Clinic, Ospedale Maggiore, P.le A. Stefani, 1, Verona 37126, Italy; emilio.pedrotti{at}


Purpose To evaluate efficacy and safety of transcutaneous application of electrical current on symptoms and clinical signs of dry eye (DE).

Methods 27 patients with DE underwent transcutaneous electrostimulation with electrodes placed onto the periorbital region of both eyes and manual stimulation with a hand-piece conductor moved by the operator. Each patient underwent 12 sessions of 22 min spread over 2 months, two sessions per week in the first month and one session per week in the second month. Ocular Surface Disease Index (OSDI) questionnaire, tear break-up time (TBUT), fluorescein staining of the cornea, Schirmer I test and adverse events were evaluated at baseline, at end of treatment and at 6 and 12 months.

Results OSDI improved from 43.0±19.2 at baseline to 25.3±22.1 at end of treatment (mean±SD, p=0.001). These effects were substantially maintained at 6-month and 12-month follow-up evaluations. Improvement of the values of TBUT was recorded for the right eye at the end of treatment (p=0.003) and found in the left eye after 12 months (p=0.02). The Oxford scores changed in both eyes at the end of treatment and at the 6-month evaluation (p<0.001), and in the right eye at the 12-month evaluation (p=0.035). Schirmer I improved significantly at the end of treatment in the left eye (p=0.001) and in both eyes at the 12-month evaluation (p=0.004 and p=0.039 for the left and right eye, respectively). A significant reduction of the use of tear substitutes was found at the end of treatment (p=0.003), and was maintained during the follow-up (p<0.001).

No complications occurred and patients found the treatment satisfying.

Conclusions Transcutaneous electrical stimulation was shown to improve DE, both subjectively and objectively, without any adverse effects and has the potential to enlarge the armamentarium for treating DE.

  • Lacrimal gland
  • Ocular surface

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