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Clinical science
Decreased severity of age-related macular degeneration in amblyopic eyes
  1. Philip P Storey1,2,
  2. Hassan A Aziz2,
  3. Ghazala A Datoo O’Keefe3,
  4. Mark Borchert2,4,
  5. Linda A Lam2,
  6. Carmen A Puliafito2,
  7. Lisa C Olmos de Koo5
  1. 1 Retina Service, Wills Eye Hospital, Philadelphia, Pennsylvania, USA
  2. 2 USC Roski Eye Institute, University of Southern California, Los Angeles, California, USA
  3. 3 Emory Eye Center, Emory University, Atlanta, Georgia, USA
  4. 4 Department of Ophthalmology, Children’s Hospital Los Angeles, Los Angeles, California, USA
  5. 5 University of Washington Eye Institute, Seattle, Washington, USA
  1. Correspondence to Dr Lisa C Olmos de Koo, University of Washington Eye Institute, Seattle, Washington, USA ; lolmos{at}uw.udu

Abstract

Aim To evaluate whether people with age-related macular degeneration (AMD) and a history of amblyopia have equal severity of AMD in both eyes.

Methods Billing records were used to locate all people with a history of amblyopia and AMD evaluated between 1 January 2003 and 1 June 2015 at a single ophthalmology institute. Two ophthalmic graders blinded to amblyopia status determined the severity of AMD in each eye using fundus photos and a validated grading scale.

Results A total of 14 people were found to have AMD and a documented history of amblyopia. Average patient age was 77.0 years and average best corrected visual acuity was 20/160 in eyes with a history of amblyopia and 20/40 in fellow eyes without amblyopia. Eyes with a history of amblyopia were found to have a lower AMD severity score (mean lower score: −1.38; paired t-test P=0.019). Of the 11 people with asymmetric disease severity, 10 individuals had worse AMD in the non-amblyopic eye while one person had worse AMD in the amblyopic eye (P=0.0067).

Conclusions Our pilot study suggests that eyes with a history of amblyopia may manifest decreased severity of AMD compared with non-ambylopic eyes in the same patient. Further research is warranted to investigate this clinical observation.

  • macula
  • child health (paediatrics)
  • degeneration
  • retina
  • visual (cerebral) cortex

http://dx.doi.org/10.1136/bjophthalmol-2017-311671

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    Footnotes

    • Contributors Concept and design of study: PPS, HAA, GDO, MB, LCOdK. Acquisition of data: PPS, HAA, GDO, LCOdK. Analysis and/or interpretation of data: PPS, HAA, GDO, MB, LCOdK. Drafting the manuscript: PPS, HAA, LCOdK. Revising the manuscript critically for important intellectual content: PPS, HAA, GDO, MB, LAL, CAP, LCOdK. Approval of the version of the manuscript to be published: PPS, HAA, GDO, MB, LAL, CAP, LCOdK.

    • Funding This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Ethics approval The Institutional Review Board of the University of Southern California Keck School of Medicine.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Presented at The project was presented at American Society of Retina Surgeons Annual Meeting 2016, San Francisco, CA, USA.

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    © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

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