Aim To evaluate whether people with age-related macular degeneration (AMD) and a history of amblyopia have equal severity of AMD in both eyes.
Methods Billing records were used to locate all people with a history of amblyopia and AMD evaluated between 1 January 2003 and 1 June 2015 at a single ophthalmology institute. Two ophthalmic graders blinded to amblyopia status determined the severity of AMD in each eye using fundus photos and a validated grading scale.
Results A total of 14 people were found to have AMD and a documented history of amblyopia. Average patient age was 77.0 years and average best corrected visual acuity was 20/160 in eyes with a history of amblyopia and 20/40 in fellow eyes without amblyopia. Eyes with a history of amblyopia were found to have a lower AMD severity score (mean lower score: −1.38; paired t-test P=0.019). Of the 11 people with asymmetric disease severity, 10 individuals had worse AMD in the non-amblyopic eye while one person had worse AMD in the amblyopic eye (P=0.0067).
Conclusions Our pilot study suggests that eyes with a history of amblyopia may manifest decreased severity of AMD compared with non-ambylopic eyes in the same patient. Further research is warranted to investigate this clinical observation.
- child health (paediatrics)
- visual (cerebral) cortex
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Contributors Concept and design of study: PPS, HAA, GDO, MB, LCOdK. Acquisition of data: PPS, HAA, GDO, LCOdK. Analysis and/or interpretation of data: PPS, HAA, GDO, MB, LCOdK. Drafting the manuscript: PPS, HAA, LCOdK. Revising the manuscript critically for important intellectual content: PPS, HAA, GDO, MB, LAL, CAP, LCOdK. Approval of the version of the manuscript to be published: PPS, HAA, GDO, MB, LAL, CAP, LCOdK.
Funding This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Ethics approval The Institutional Review Board of the University of Southern California Keck School of Medicine.
Provenance and peer review Not commissioned; externally peer reviewed.
Presented at The project was presented at American Society of Retina Surgeons Annual Meeting 2016, San Francisco, CA, USA.
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