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14-year case series of eyelid sebaceous gland carcinoma in Chinese patients and review of management
  1. Stacey C Lam1,2,
  2. Emmy Y M Li1,2,
  3. Hunter K L Yuen1,2
  1. 1 Department of Ophthalmology, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong, China
  2. 2 Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China
  1. Correspondence to Dr Stacey C Lam, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong, China; staceylam{at}


Aims Sebaceous gland carcinoma (SGC) of the eyelid is a rare but potentially deadly cancer. The purpose of this study was to determine whether the American Joint Committee on Cancer (AJCC) 7th Edition T category for SGC correlated with metastasis and survival in the Chinese population.

Methods This was a retrospective, single-centre cohort study. Patients with surgically resected eyelid SGC between January 2001 and May 2015 at the Hong Kong Eye Hospital were reviewed. Tumours were staged using the AJCC criteria. The main outcome measures included local recurrence, metastasis and death. Disease-free survival (DFS) was measured from the completion of treatment; overall survival was measured from the date of initial diagnosis.

Results The study included 22 Chinese patients with a mean age of 65.4 years. The majority presented as a nodular lesion (91%) with 12 eyes (54.5%) initially misdiagnosed and a mean presentation time of 1 year. It was found that those with AJCC stage T2b or higher were significantly associated with lymph node metastasis (P=0.002) when compared with those with stage T2a. Older age at diagnosis (P=0.035) and no misdiagnosis (P=0.025) were associated with shorter DFS. Those with stage 3a or higher were associated with shorter DFS (P=0.007) and overall survival (P=0.024).

Conclusion Similar to previous reports, in this Chinese cohort, AJCC staging for SGC correlated with lymph node metastasis, DFS and overall survival. Those with stage 2b or higher on presentation will need closer surveillance for lymph node metastasis and may benefit from sentinel lymph node biopsy.

  • sebaceous carcinoma
  • malignant eyelid tumour
  • Hong Kong
  • lymph node metastasis
  • AJCC

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  • Contributors All authors have contributed to the implementation of the research. SCL took the lead in the analysis and writing of the manuscript.

  • Competing interests None declared.

  • Patient consent Detail has been removed from this case description/these case descriptions to ensure anonymity. The editors and reviewers have seen the detailed information available and are satisfied that the information backs up the case the authors are making.

  • Ethics approval Institutional Review Board of the Kowloon Central Cluster, Hospital Authority, Hong Kong.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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