Purpose To report the long-term anatomical and visual outcomes of intravitreal bevacizumab (IVB) monotherapy in naive choroidal neovascularisation (CNV) caused by myopia.
Methods Retrospective analysis of naive CNV secondary to myopia that underwent antivascular endothelial growth factor monotherapy was performed. Collected data included demographic details, clinical examination details including visual acuity at presentation and follow-up with imaging and treatment details. Main outcome measures were resolution of CNV activity at the last visit. Secondary outcomes included change in visual acuity, number of injections and adverse events.
Results Thirty-three eyes of 31 subjects with a mean age of 51.48±16.4 years were included. The mean follow-up was 66.47 months. 27 eyes had type 2 CNV and the rest seven eyes had type 1 CNV. The mean number of IVB injections per eye was 4.9. Mean visual acuity at baseline reduced from 0.65±0.33 logMAR units (Snellen equivalent=20/89) to 0.73±0.50 logMAR units (20/107) at final follow-up (p=0.003). The mean central macular thickness decreased from 309.31±86 µm at baseline to 267.5±70.89 µm at the last visit (p=0.03). However, visual acuity was maintained (±1 line of baseline) in 13 eyes (39.4%), ≥2 line improvement in nine (27.3%) eyes and more than two lines worsening in 11 eyes (33.3%). Foveal atrophy was observed at baseline and last visit in 6 (12.5%) and 14 (29.1%), respectively (p=0.007). No systemic adverse events were observed.
Conclusion IVB monotherapy is safe and effective for long-term treatment of CNV secondary to myopia in real life.
- choroidal neovascularization
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Contributors JC and JFA designed the study. LW, CC, MM, SL, SR, MS, MHB, RFL and JFA conducted the study and collected the data. JC, RMP and JFA were involved in the management, analysis and interpretation of the data and preparation of the manuscript. JC, RM, LW, CC, MM, SL, SR, MS, MHB, RFL and JFA did the review and approval of the final manuscript.
Competing interests None declared.
Patient consent Obtained.
Ethics approval Institutional ethics committee.
Provenance and peer review Not commissioned; externally peer reviewed.
Collaborators For a complete listing of participating members of PACORES, see online appendix.
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