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Comparative analysis of autofluorescence and OCT angiography in Stargardt disease
  1. Abhilash Guduru1,
  2. Marco Lupidi2,3,
  3. Arushi Gupta4,
  4. Subhadra Jalali4,
  5. Jay Chhablani4
  1. 1 School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
  2. 2 Centre de l’Od’eon, Paris, France
  3. 3 Department of Biomedical and Surgical Sciences, Section of Ophthalmology, University of Perugia, S Maria della Misericordi Hospital, Perugia, Italy
  4. 4 Department of Smt Kanuri Santhamma Centre for Vitreo Retinal Diseases, LV Prasad Eye Institute, Hyderabad, India
  1. Correspondence to Dr Jay Chhablani, Department of Smt Kanuri Santhamma Centre for Vitreo Retinal Diseases, L V Prasad Eye Institute, Hyderabad 500034, India; jay.chhablani{at}


Aims To characterise the vasculature of the retina in patients with Stargardt disease (STGD) using optical coherence tomography angiography (OCTA) and to compare these functional findings with fundus autofluorescence (FAF) imaging.

Methods This observational study included consecutive patients with STGD. The choriocapillaris (CC) layer was analysed on OCTA and retinal pigment epithelium (RPE) changes were assessed on FAF. Areas of CC and RPE impairment were quantified and correlated.

Results Twenty-two patients suffering from different stages of STGD were enrolled. OCTA revealed a vascular rarefaction with vascular prominence in 15 (35%) eyes while the remaining cases had pure vascular rarefaction. On FAF imaging, 25 (58%) eyes had a peripapillary halo, a hypofluorescent lesion in foveal area and the presence of both hypofluorescent and hyperfluorescent changes. On FAF imaging, the average area of RPE impairment was 6.7±4.4 mm2 while on OCTA a hypointense area of 4.2±3.6 mm2 was shown at the level of the CC layer. Mann-Whitney U test showed a statistically significant difference in terms of lesion extension between these two findings (p=0.004).

Conclusion RPE damage on FAF appears to be significantly larger than CC layer vessel loss on OCTA, which suggests that RPE damage might precede that of CC.

  • retina
  • imaging

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  • Contributors Design of the study: AR, SJ and JC; conduct of the study: AR, AB, ML, SJ and JC; collection of the manuscript: AR, ML, SJ and JC: management of the manuscript: JC and AR; analysis of the manuscript: AR, AB and JC; interpretation of the manuscript: AR, AB and JC; preparation of the manuscript: AR, AB, SJ and JC; review of the manuscript: AR, AB, ML, SJ and JC; approval of the manuscript: AR, AB, ML, SJ and JC.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval The study was approved by the Institutional Review Board of the institute and all the methods adhered to the tenets of the Declaration of Helsinki.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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