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Trabeculectomy bleb needling and antimetabolite administration practices in the UK: a glaucoma specialist national survey
  1. Karl Mercieca1,
  2. Brett Drury1,
  3. Archana Bhargava2,
  4. Cecilia Fenerty1
  1. 1 Glaucoma Unit, Manchester Royal Eye Hospital, Manchester, UK
  2. 2 Eye Unit, Aintree University Hospitals NHS Foundation Trust, Liverpool, UK
  1. Correspondence to Mr Karl Mercieca, Manchester Royal Eye Hospital, Manchester M13 9WL, UK; karl.mercieca{at}


Aims To evaluate, describe and quantify the diversity in postoperative antimetabolite administration and bleb needling practices among glaucoma specialists performing trabeculectomy surgery within the UK and Ireland.

Methods A cross-sectional online survey was distributed to all consultant glaucoma specialists who are on the United Kingdom and Eire Glaucoma Society (UKEGS) contact list. Participants were asked specific questions about their current practices for post-trabeculectomy antimetabolite administration followed by questions directly related to bleb needling procedures.

Results 60 (83%) of UKEGS glaucoma subspecialty consultants completed the survey. 70% of respondents administered 5-fluorouracil (5-FU) in their clinic room while 30% used a separate treatment room. Doses of 5-FU varied considerably but 70% used 5 mg as standard. Techniques used to reduce corneal toxicity included precipitation with amethocaine (44%) or benoxinate (14%), saline wash (14%) and modified injection technique (8%). Topical antibiotics and/or betadine were used to prevent infection following 5-FU injection in just over 50%. Bleb needling was exclusively performed in operating theatre by 56% of respondents and solely at the slit lamp in the clinic room by 12%. A further 30% used a combination of both theatre and outpatient clinic rooms. Anti-metabolites used were 5-FU (72%) and mitomycin C (22%) with 12% using either of the two substances.

Conclusions There is a significantly wide variety of current practices for antimetabolite administration and bleb needling within the UK and Ireland. This may be influenced by a glaucoma surgeon’s specific experience and audit results as well as particular clinical set-up, availability of antimetabolite and clinic room space.

  • glaucoma
  • treatment surgery
  • wound healing

Statistics from


  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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