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Normative pattern and determinants of outer retinal thickness in an Asian population: the Singapore Epidemiology of Eye Diseases Study
  1. Wei Dai1,
  2. Yih-Chung Tham1,
  3. Miao-Li Chee1,
  4. Shivani Majithia1,
  5. Nicholas Y Q Tan1,
  6. Kah-Hie Wong1,2,
  7. Kumari Neelam1,
  8. Ning Cheung1,3,
  9. Charumathi Sabanayagam1,3,
  10. Carol Y Cheung4,
  11. Tien-Yin Wong1,2,3,
  12. Ching-Yu Cheng1,2,3
  1. 1 Singapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore
  2. 2 Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  3. 3 Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore
  4. 4 Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China
  1. Correspondence to Dr Ching-Yu Cheng, Singapore National Eye Centre, Singapore Eye Research Institute, Singapore 169856, Singapore; chingyu.cheng{at}duke-nus.edu.sg

Abstract

Background/aims To evaluate the distribution and determinants of outer retinal thickness in eyes without retinal diseases, using spectral-domain optical coherence tomography (SD-OCT).

Methods Participants were recruited from the Singapore Epidemiology of Eye Diseases Study, a population-based study among Chinese, Malays and Indians in Singapore. A total of 5333 participants underwent SD-OCT imaging in which a 6×6 mm2 measurement area centred at the fovea. Outer retinal thickness was defined as the distance from the outer plexiform layer to the retinal pigment epithelium layer boundary.

Results 7444 eyes from 4454 participants were included in final analysis. Of them, mean age was 58.4 years (SD 8.3), and 2294 (51.5%) were women. Women (121.0±8.1 µm) had thinner average outer retinal thickness than men (125.6±8.2 µm) (p<0.001). Malays (121.4±8.7 µm) had thinner average outer retinal thickness than Indians (124.3±8.6 µm) and Chinese (123.7±7.9 µm) (both p<0.001). In multivariable models, thinner average outer retinal thickness was associated with older age (per decade, β=−1.02, p<0.001), hypertension (β=−0.59, p=0.029), diabetes (β=−0.73, p=0.013), chronic kidney disease (β=−1.25, p=0.017), longer axial length (per mm, β=−0.76, p<0.001), flatter corneal curvature (per mm, β=−2.00, p<0.001) and higher signal strength (β=−1.46, p<0.001).

Conclusion In this large sample of Asian population, we provided normative SD-OCT data on outer retinal thickness in eyes without retinal diseases. Women had thinner outer retina than men. For the first time, these findings provide fundamental knowledge on normative profile of outer retinal thickness in Asians.

  • epidemiology
  • retina
  • imaging
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Footnotes

  • Contributors WD: substantial contributions to the conception and design of study, the analysis and interpretation of data, drafting the work and revising it critically for important intellectual content, final approval of version to be published. Y-CT, M-LC, SM, NYQT, K-HW, KN, NC, CS, CYC, T-YW: substantial contributions to analysis and interpretation of data, revising the article critically for important intellectual content, final approval of version to be published. C-YC: substantial contributions to the conception and design of study, analysis and interpretation of data, revising the article critically for important intellectual content, final approval of version to be published and agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

  • Funding This study is supported by the National Medical Research Council (NMRC/1249/2010, NMRC/CIRG/1371/2013, NMRC/CIRG/1417/2015 and NMRC/CIRG/1488/2018) and Biomedical Research Council (08/1/35/19/550), Singapore. C-YC is supported by the National Medical Research Council (NMRC/CSA-SI/0012/2017).

  • Competing Interests None declared.

  • Patient consent for publication Obtained.

  • Ethics approval The SingHealth Centralized Institute Review Board.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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