Aim To evaluate and correlate mean light sensitivity thresholds (MLST) in patients with congenital stationary night-blindness (CSNB) in comparison with healthy subjects using microperimetry (MP1).
Methods Eleven patients with CSNB and 13 healthy subjects were compared. In all subjects, static threshold perimetry was performed using MP1 evaluating the central 6 mm of the retina. This central retinal area was divided into three rings through using the ETDRS grid algorithm with an innermost (1 mm), inner (3 mm) and outer ring (6 mm). The MLSTs were acquired in nine sectors of the ETDRS grid. A comparison of MLST was performed between both groups using a t-test (significance level p<0.005).
Results A significant reduction of MLST in the fovea (innermost ring, 1 mm) was observed for patients with CSNB (7.2±3.90 dB) in comparison to healthy subjects (19.7±0.75; p<0.0001). Similarly, comparison of MLST in all other sectors (superior/inferior/temporal and nasal) within the inner and outer ring revealed a statistically significant reduction in patients with CSNB compared with healthy subjects (p<0.001).
Conclusions Examination of macular retinal sensitivity intensity using MP1 revealed for the first time a significant reduction of MLST within the central 6 mm of the retina in patients with CSNB compared with healthy subjects. This finding supports MP1 as an additional diagnostic tool when examining patients with retinal dysfunctions such as CSNB.
- field of vision
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Contributors AW is responsible for the overall content as guarantor. AS and EZ had the idea for this study. AW, AS, FG, SK, CZ, GW and KUBS contributed to the data acquisition, analysis and scientific discussion of the results.
Funding This study was supported by the Fortüne programme of the University of Tübingen (Fortüne number 2079-0-0).
Competing interests None declared.
Patient consent for publication Obtained.
Ethics approval Ethics Committee of the University of Tübingen. The study was approved by the local ethics committee (project number 129/211BO9).
Provenance and peer review Not commissioned; externally peer reviewed.