Purpose To investigate the choroidal thickness (CT) and choroidal vascular densities (CVD) of patients with macular telangiectasia type 2 (MacTel2) and their association with other multimodal imaging features, using swept-source optical coherence tomography (SS-OCT).
Methods Prospective, cross-sectional study. Consecutive patients with MacTel2 along with controls without any macular disease were included. Fundus photography, confocal blue reflectance, near-infrared reflectance, autofluorescence, fluorescein angiography, spectral domain OCT and SS-OCT were performed. Images were independently analysed by two graders, and CVD was calculated from binarised en face SS-OCT images. CT was obtained from the SS-OCT platform via built-in automated segmentation. Multilevel mixed-effects models were used for statistical analysis.
Results Thirty-nine eyes of 20 patients with MacTel2 and 29 eyes of 15 control patients were included. Average CT and perifoveal temporal CT did not differ significantly between eyes with MacTel2 and control eyes (p≥0.350), when accounting for confounding factors. Overall and temporal CVD also did not significantly differ between the two groups (p≥0.490).
Conclusion CT and CVD did not significantly differ between MacTel2 and control eyes in this study using SS-OCT. Even though MacTel2 may include abnormalities involving the choroid, these are likely minor in comparison to the predominant retinal changes.
- choroidal thickness
- choroidal vessel density
- macular telangiectasia type 2
- multimodal imaging
- swept-source optical coherence tomography
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Contributors JCW, IL: substantial contributions to the conception and design of the work, and acquisition, analysis and interpretation of data for the work; substantial contributions to drafting the work and revising it critically for important intellectual content. PO: substantial contributions to the analysis and interpretation of data for the work. IKK, JWM: substantial contributions to the interpretation of data for the work. JBM: substantial contributions to the conception and design of the work, and acquisition, analysis and interpretation of data for the work. PO, IKK, JWM, JBM: substantial contributions to revising the work critically for important intellectual content. All authors were involved in the final approval of the version to be published, and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Not required.
Ethics approval Institutional Review Board of Massachusetts Eye and Ear.
Provenance and peer review Not commissioned; externally peer reviewed.
Author note This work was completed at Massachusetts Eye and Ear.