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Optical coherence tomography angiography findings in cystoid macular degeneration associated with central serous chorioretinopathy
  1. Niroj Kumar Sahoo1,
  2. Sai Bhakti Mishra1,
  3. Claudio Iovino2,
  4. Sumit Randhir Singh1,
  5. Marion R Munk3,4,
  6. Lieselotte Berger3,
  7. Enrico Peiretti2,
  8. Jay Chhablani1
  1. 1 Smt. Kanuri Santhamma Centre for Vitreo Retinal Diseases, L V Prasad Eye Institute, Hyderabad, India
  2. 2 Department of Surgical Science, Eye Clinic, University of Cagliari, Cagliari, Italy
  3. 3 Department of Ophthalmology, Bern, Inselspital, Bern University Hospital, University of Bern, Switzerland
  4. 4 Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
  1. Correspondence to Dr Jay Chhablani, L V Prasad Eye Institute, Hyderabad 500034, India; jay.chhablani{at}


Aim To describe the optical coherence tomography (OCT) characteristics and to identify and analyse the incidence of choroidal neovascular (CNV) network seen on optical coherence tomography angiography (OCTA) in eyes with cystoid macular degeneration (CMD) associated with central serous chorioretinopathy (CSCR).

Methods This was a retrospective, observational study of 29 eyes of 25 patients who were previously diagnosed as CSCR with CMD. Baseline patient characteristics, best-corrected visual acuity (BCVA), evidence of CNV network and its pattern on OCTA, distribution of CMD changes and OCT parameters, such as height of the neurosensory retinal detachment (NSD), presence of double layer sign, central macular thickness, were analysed. The eyes were classified into two groups depending on the presence or absence of CNV network on OCTA. BCVA, OCT parameters and CMD distribution were compared in the two groups at baseline using independent t-test.

Result A total of 13 (44.8 %) eyes had a CNV network, while only 9 out of the 13 eyes had pattern-I CNV. Among the eyes with CNV network (13 eyes), mean height of NSD was of 65.2±22.7 µ, whereas, among the eyes without CNV (16 eyes), it was 134.6±77.4 µ. The difference was statistically significant (p=0.013). There was no statistically significant difference between eye having a CNV and eyes without CNV in terms of other parameters.

Conclusion A CNV network is seen in a large subset of patients with CMD in CSCR. A shallower subretinal fluid may point towards the presence of an underlying CNV network.

  • central serous chorioretinopathy
  • CSCR
  • OCT angiography
  • cystoid macular degeneration
  • choroidal neovascularisation

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  • Contributors MRM, EP and JC: design. SBM and NKS: conduct of the study. SBM: collection. NKS: management. NKS, SBM, CI and SRS: analysis. NKS and CI: interpretation of the data. NKS, SBM, CI and SRS: preparation. MRM, LB, EP and JC: review. MRM, LB, EP and JC: approval of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Ethics approval Hyderabad Eye Research Foundation, LV Prasad Eye Institute.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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