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Association of human antigen class I genes with cold medicine-related Stevens-Johnson syndrome with severe ocular complications in a Korean population
  1. Ikhyun Jun1,2,
  2. John Hoon Rim2,3,
  3. Mee Kum Kim4,
  4. Kyung-Chul Yoon5,
  5. Choun-Ki Joo6,
  6. Shigeru Kinoshita7,
  7. Kyoung Yul Seo1,
  8. Mayumi Ueta7
  1. 1 Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea
  2. 2 Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea
  3. 3 Department of Medicine, Physician-Scientist Program, Yonsei University Graduate School of Medicine, Seoul, Korea
  4. 4 Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea
  5. 5 Department of Ophthalmology, Chonnam National University, Gwangju, Korea
  6. 6 Department of Ophthalmology and Visual Science, Seoul St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
  7. 7 Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
  1. Correspondence to Dr Mayumi Ueta, Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan; mueta{at}koto.kpu-m.ac.jp; Dr Kyoung Yul Seo, Department of Ophthalmology, Yonsei University College of Medicine, Seoul 03722, Korea; seoky{at}yuhs.ac

Footnotes

  • Contributors MKK, KCY, CKJ, SK, KYS, MU: conceived and designed the study. SK, MU: conducted the experiments. IJ, JHR: analysed the results. IJ, KYS, MU: wrote the main manuscript. MKK, KCY, CKJ, SK: did critical revision of the manuscript for important intellectual content. All authors contributed to the review of the literature, in drafting the manuscript and in approving the final manuscript.

  • Funding This work was supported partly by grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology of the Japanese government and the JSPS Core-to-Core Program, A. Advanced Research Networks (MU) and grants NRF-2013M3A9D5072551 (KYS) from the Bio & Medical Technology Development Program of the National Research Foundation funded by the Ministry of Science, ICT and Future Planning.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Ethics approval The study was approved by the institutional review board of of the Yonsei University College of Medicine, Seoul National University College of Medicine, Chonnam National University Medical School and College of Medicine, Catholic University of Korea and Kyoto Prefectural University of Medicine.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • Contributors MKK, KCY, CKJ, SK, KYS, MU: conceived and designed the study. SK, MU: conducted the experiments. IJ, JHR: analysed the results. IJ, KYS, MU: wrote the main manuscript. MKK, KCY, CKJ, SK: did critical revision of the manuscript for important intellectual content. All authors contributed to the review of the literature, in drafting the manuscript and in approving the final manuscript.

  • Funding This work was supported partly by grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology of the Japanese government and the JSPS Core-to-Core Program, A. Advanced Research Networks (MU) and grants NRF-2013M3A9D5072551 (KYS) from the Bio & Medical Technology Development Program of the National Research Foundation funded by the Ministry of Science, ICT and Future Planning.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Ethics approval The study was approved by the institutional review board of of the Yonsei University College of Medicine, Seoul National University College of Medicine, Chonnam National University Medical School and College of Medicine, Catholic University of Korea and Kyoto Prefectural University of Medicine.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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