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Eighteen-year prospective audit of LASIK outcomes for myopia in 53 731 eyes
  1. Daniel Chua1,2,
  2. Hla Myint Htoon1,2,
  3. Li Lim1,2,
  4. Cordelia ML Chan1,2,
  5. Jodhbir S. Mehta1,2,
  6. Donald T H Tan1,2,
  7. Mohamad Rosman1,2
  1. 1 Singapore National Eye Centre, Singapore, Singapore
  2. 2 Singapore Eye Research Institute, Singapore, Singapore
  1. Correspondence to Dr Mohamad Rosman, Singapore National Eye Centre, Singapore 168751, Singapore; rosman_sg{at}


Background To assess the outcomes of laser-assisted in situ keratomileusis (LASIK) performed for the treatment of myopia in terms of safety, efficacy and predictability in an 18-year clinical audit.

Method In this single-centre, prospective, non-randomised study, preoperative and postoperative refractions, uncorrected (UCVA), best-corrected Snellen visual acuity (BCVA) and complications of all eyes undergoing myopic LASIK were recorded. Safety, efficacy, refractive predictability, treatment trends, retreatment rates and complication rates were evaluated.

Results Between 1998 and 2015, 53 731 eyes of 27312 patients underwent myopic LASIK. Patients’ median age was 31.6 years (mean, 32.6±7.3 years); there were 9703 males (35.5%). Patients were predominantly ethnic Chinese (87.4%). Mean follow-up time was 78±75.6 days (median, 86 days). Overall efficacy index was 0.91 with >99% of eyes achieving UCVA of ≥20/40 and >70% achieving 20/20 since 2010. 95.43% of eyes had no loss of vision postoperatively and 4.2% and 0.37% lost 1 and ≥2 lines BCVA, respectively. From 2010 the safety index has been >1.05. More than 94.0% of eyes achieved within ±1.0 D of target refraction and at least 70% achieved within ±0.50 D of target from 2010 onwards. Retreatment rate was 2.55% and after retreatment 98.4% of eyes achieved ≥20/40 UCVA and 63.5% achieved ≥20/20 UCVA. The overall complication rate is 0.98%, and since 2010, the annual complication rate has been <0.8%.

Conclusions Myopic LASIK performed in Asian eyes is safe and effective with high refractive predictability in a comprehensive LASIK programme with appropriate clinical audit.

  • treatment lasers
  • vision

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  • Contributors DC and RM were involved in study concept and design. DC, HHM and RM performed data analysis and interpretation. DC and RM drafted the manuscript. LL, CC, JSM, DT and RM helped revised the article. All authors have read and approved the final manuscript.

  • Funding This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Not required.

  • Ethics approval This study adhered to the tenets of the Helsinki Declaration and the SingHealth Centralized Institutional Review Board ruled that approval was not required for this study.

  • Provenance and peer review Not commissioned; internally peer reviewed.