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Topographic correlation between macular superficial microvessel density and ganglion cell-inner plexiform layer thickness in glaucoma-suspect and early normal-tension glaucoma
  1. Jin-Soo Kim1,
  2. Young Kook Kim1,
  3. Sung Uk Baek2,
  4. Ahnul Ha1,
  5. Yong Woo Kim1,
  6. Jin Wook Jeoung1,
  7. Ki Ho Park1
  1. 1 Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea
  2. 2 Department of Ophthalmology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of Korea
  1. Correspondence to Dr Ki Ho Park, Ophthalmology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; kihopark{at}snu.ac.kr

Abstract

Background/Aims To investigate the topographic relationship between macular superficial microvessel density (SMD) and macular ganglion cell-inner plexiform layer (GCIPL) thickness in eyes with glaucoma-suspect (GS) and early normal-tension glaucoma (NTG).

Methods A total of 86 eyes of 86 patients with early NTG (standard automated perimetry mean deviation >−5.5 decibels) and a total of 25 eyes of 25 patients with GS were retrospectively reviewed. All of the subjects underwent optical coherence tomography (OCT) and OCT angiography (OCTA) scan. On the OCTA scan images, macular SMD was analysed by customised software.

Results In GS and patients with early NTG, macular GCIPL thickness showed significant correlations with macular SMD in the superotemporal (ST), inferotemporal (IT) and inferoinferior (II) sectors (r =0.191, 0.373 and 0.346 for ST, IT and II sector, respectively). Additionally, circumpapillary retinal nerve fibre layer (RNFL) thickness and macular SMD showed significant correlations between the ST sector of the macula and the 1, 9 clock-hour peripapillary regions and between the IT and II sectors of the macula and the 6, 7, 8 clock-hour peripapillary regions. The IT sector macular SMD showed fair diagnostic power (area under the receiver operating characteristic curve [AUROC] = 0.758) and showed high diagnostic power when combined with IT sector macular GCIPL thickness (AUROC=0.954).

Conclusions Sectoral macular SMD showed topographic correlations with macular GCIPL thickness and circumpapillary RNFL thickness in patients with GS and early-stage NTG. Macular SMD analysis is potentially useful in the clinical evaluation of early glaucoma.

  • glaucoma
  • imaging

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Footnotes

  • Contributors J-SK: data collection, data analysis and interpretation, drafting the article. YKK, SUB: data analysis and interpretation, critical revision of the article. AH, YWK, JWJ: critical revision of the article. KHP: design of the work, critical revision and final approval of the article to be published.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval Seoul National University Hospital Institutional Review Board (IRB No. 1805-185-950).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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