Article Text

Download PDFPDF

Effect of a formulated eye drop with Leptospermum spp honey on tear film properties
  1. Jacqueline Tan,
  2. Tianni Jia,
  3. Roslyn Liao,
  4. Fiona Stapleton
  1. School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia
  1. Correspondence to Dr Jacqueline Tan, University of New South Wales School of Optometry and Vision Science, Sydney, NSW2052, Australia; jacqueline.tan{at}unsw.edu.au

Abstract

Aim To evaluate the effects of a proprietary formulated eye drop with Leptospermum spp honey versus a conventional lubricant eye drop on tear film properties in subjects with symptoms related to dry eye disease after 28 days of treatment.

Methods Forty-six subjects with symptoms related to dry eye (Ocular Surface Disease Index (OSDI) score >12) were enrolled and randomly assigned to receive either the test formulated eye drop (Optimel by Melcare Biomedical Pty Ltd) or control eye drops (Alcon, USA) in this double-masked study. Inferior lipid layer thickness (LLT), tear film evaporation rate (TER), fluorescein tear film break-up time (TBUT), corneal staining and subjective symptoms (OSDI and visual analogue scales (VAS)) were measured before and after 28 days of instilling the eye drops.

Results Forty-two subjects completed the study (21 subjects in each group). After 28 days of treatment, TER showed a significantly greater reduction with the formulated eye drop compared with the control (p=0.01). TBUT showed a slight but not statistically significant increase with the formulated eye drop compared with the control (p=0.06), and a significantly greater reduction (improvement) in OSDI scores was observed with the formulated eye drop compared with the control (p=0.01). No significant differences were found between the two groups for inferior LLT, corneal staining and any of the VAS scores.

Conclusions The formulated eye drops were effective in reducing tear film evaporation rate and were more effective for improving symptoms of dry eye compared with the control eye drops after 28 days of treatment.

Trial registration number NCT03622619.

  • tears
  • ocular surface

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

View Full Text

Statistics from Altmetric.com

Footnotes

  • Contributors All authors took an active part in the design, conduct, data analysis, and publication drafting and approval.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Ethics approval University of New South Wales (UNSW) Human Research Ethics Committee (HC180256).

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available on request. All data relating to the study are published. Any requests for data can be made to the corresponding author and are subject to ethics approval.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.