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Predictors of selective laser trabeculoplasty success in open angle glaucoma or ocular hypertension: does baseline tonography have a predictive role?
  1. Pouya Alaghband1,2,
  2. Elizabeth Angela Galvis2,
  3. Arij Daas2,
  4. Anindyt Nagar2,
  5. Laura Beltran-Agulló3,
  6. Anthony P Khawaja4,
  7. Saurabh Goyal2,
  8. Kin Sheng Lim1,2
  1. 1 Ophthalmology, King’s College London, London, UK
  2. 2 Ophthalmology, St Thomas Hospital, London, United Kingdom
  3. 3 Ophthalmology, Institut Català de la Retina, Barcelona, Spain
  4. 4 Ophthalmology, Moorfields Eye Hospital, London, UK
  1. Correspondence to Mr Kin Sheng Lim, Ophthalmology, St Thomas Hospital, London SE1 7EH, UK; shenglim{at}


Background The determinants of success of selective laser trabeculoplasty (SLT) in treatment-naïve patients with open angle glaucoma (OAG) and ocular hypertension (OHT) have not been understood fully. Therefore, we have conducted this study to explore the predictors of success.

Methods This is a retrospective review of a pre-existing database of patients who had received primary SLT at St Thomas’ Hospital, London, UK. Patients with OAG and OHT who had received primary 360° SLT treatment and had reliable baseline tonographic outflow facility (TOF) with minimum of 1 year of follow-up were included. Univariate and multivariate analyses were performed to find the determinants of success.

Results One hundred and seventy-four patients between August 2006 and February 2010 had received primary 360° SLT treatment and had baseline TOF measurement. Of these, 72 subjects fulfilled the eligibility criteria. In multivariate regression analysis, the only variable associated with success was baseline intraocular pressure (IOP) (R2=0.32, beta=−0.51, p<0.001, 95% CI −2.02 to −0.74).

Conclusion To our knowledge, this is the only study investigating the pretreatment TOF (measured with electronic Shiøtz tonography) and IOP as determinants of success 12 month’s post-360° SLT in treatment-naïve patients with OAG and OHT. This study demonstrated that pretreatment IOP (and not TOF) is the only determinant of success after primary SLT therapy.

  • aqueous humour
  • glaucoma
  • intraocular pressure
  • treatment lasers

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  • This work was presented at the annual Association of Research in Vision and Ophthalmology (ARVO) 2012, Fort Lauderdale, FL, USA.

  • Twitter Pouya Alaghband @pouyaalaghband

  • Contributors PA and KSL conceived the study. PA, EAG, LB-A and SG have collected and collated the data. PA has performed data analysis. All authors have contributed equally to manuscript preparation.

  • Funding KSL is funded by the NIHR, Biomedical Research Centre, Guy’s & St Thomas’ NHS Foundation Trust, London, UK.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data will be available on reasonable request.