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Three-year follow-up of choroidal neovascularisation in eyes of chronic central serous chorioretinopathy
  1. Yen-Chih Chen1,2,
  2. San-Ni Chen1,3,4,5
  1. 1Ophthalmology, Changhua Christian Hospital, Changhua City, Taiwan
  2. 2Ophthalmology, Changhua Christian Hospital Yunlin Branch, Xiluo, Yunlin, Taiwan
  3. 3School of Medicine, Chung-Shan Medicaul University, Changhua, Taiwan
  4. 4School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
  5. 5Optometry, Da-Yeh University, Changhua, Taiwan
  1. Correspondence to Dr San-Ni Chen, Ophthalmology, Changhua Christian Hospital, Changhua, Taiwan; 108562{at}


Aims This study aimed to report the 3-year follow-up results of the clinical course and structural changes of choroidal neovascularisation (CNV) by optical coherence tomography angiography (OCT-A) in eyes with a history of chronic central serous chorioretinopathy (CSC).

Methods This is a retrospective study of patients with chronic CSC complicated with CNV. Patients were recorded of best-corrected visual acuity (BCVA) and treatment modalities. OCT was used to evaluate the presence of subretinal fluid (SRF), type of CNV, changes in central retinal thickness (CRT) and subfoveal choroidal thickness (SFCT). Changes in the size, vessel density (VD) and morphology of CNV were evaluated by OCT-A. Comparison between baseline and final parameters was made.

Results A total of 30 eyes in 26 patients, most of whom had previous treatment for chronic CSC, were included with a mean follow-up period of 40.37±4.11 months. No changes in BCVA were noted (p=0.562). During the 3-year follow-up period with OCT-A, five eyes had SRF noted. The other 25 eyes remained SRF free throughout the course. Regarding the morphological changes, the size of CNV enlarged significantly (p<0.01); VD of CNV decreased significantly (p=0.01); and the number of CNV with visible core vessel significantly increased (p<0.01). A significant reduced SFCT was noted (p=0.02), while the CRT remained unchanged (p=0.855).

Conclusion For most eyes infected with chronic CSC receiving previous treatment for the activity of chronic CSC, with CNV subsequently found on OCT-A, a midterm stable clinical course up to 3 years was noted, despite significant structural changes of CNV evaluated by OCT-A.

  • neovascularisation

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  • Contributors Design and conduct of the study: S-NC. Collection of data: Y-CC, S-NC. Analysis and interpretation of data: Y-CC, S-NC. Writing the article: Y-CC. Critical revision of the article: S-NC. Final approval of the article: Y-CC, S-NC.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Ethics approval The study was approved by the Ethics Committee and Research Board of Changhua Christian Hospital and adhered to the Declaration of Helsinki.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available on reasonable request. The data will be available from the IRB, Changhua Christian Hospital, Taiwan.