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The recent publication by Hindso et al 1 confirmed the excellent outcome of extranodal marginal zone B-cell lymphoma of the ocular adnexa (OA-EMZL) with external beam radiation therapy (EBRT) as a stand-alone therapy, with an impressive 95% rate of 10-year disease-free survival. In the largest study to date of OA-EMZL patients from seven eyes cancer centres, 352 patients received EBRT as first treatment of localised disease with a median radiation dose of 26 Grays (Gy) (range 4–60 Gy) and the authors concluded that low-dose EBRT would appear to be the best treatment of choice in localised OA-EMZL.1 This important study does not display data regarding the number of patients that received the very low-dose radiation therapy (VLDRT) of 4 Gy. It would also be interesting to report long-term effects based on the dose received. These elements are required to discuss the benefit of low-dose EBRT because of the unfavourable prognosis of the relapses of these OA-EMZL1 and the risk of cataract formation.2 The risk of cataract was associated with delivered dose >30 Gy and omitted …
Contributors Conception and design, administrative support, provision of study materials or patients, collection and assembly of data, data analysis and interpretation, manuscript writing, final approval of manuscript: all authors.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests HT: Gilead: Honoraria; Takeda: Consultancy, Honoraria; Celgene: Consultancy, Honoraria, Membership on an entity’s Board of Directors or advisory committees, Research Funding; Karyopharm: Consultancy, Honoraria, Membership on an entity’s Board of Directors or advisory committees; Roche: Consultancy, Honoraria, Membership on an entity’s Board of Directors or advisory committees, Research Funding; Janssen: Consultancy, Honoraria, Membership on an entity’s Board of Directors or advisory committees; Immunogen: Honoraria. VC: Gilead: Honoraria—Amgen: Honoraria—BMS: Honoraria; Roche: Consultancy, Honoraria, Membership on an entity’s Board of Directors or advisory committees. FJ: Roche: Honoraria; Janssen: Honoraria; Celgen: Honoraria.
Patient consent for publication Not required.
Provenance and peer review Not commissioned; externally peer reviewed.
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