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Comparison of corneal densitometry between big-bubble and visco-bubble deep anterior lamellar keratoplasty
  1. Vincenzo Scorcia1,
  2. Valentina De Luca1,
  3. Andrea Lucisano1,
  4. Donatella Bruzzichessi1,
  5. Marco Balestrieri1,
  6. Mauro Soda1,
  7. James Myerscough2,
  8. Massimo Busin3
  1. 1 Ophthalmology, University of Magna Graecia, Catanzaro, Italy
  2. 2 IRFO Istituto Internazionale di Ricerca e Formazione in Oftalmologia, Forlì, Italy
  3. 3 Ophthalmology, Villa Igea Hospital, Forli, Italy
  1. Correspondence to Dr Vincenzo Scorcia, Ophthalmology, University of "Magna Graecia, Catanzaro 88100, Italy; vscorcia{at}


Aims To evaluate deep corneal densitometry and visual outcomes after big-bubble (BB-DALK) and visco-bubble (VB-DALK) deep anterior lamellar keratoplasty performed in patients with keratoconus.

Methods Prospective comparative study of 50 advanced keratoconic patients who underwent DALK surgery; 25 eyes (group I) were completed with BB-DALK and 25 eyes (group II) with VB-DALK after the failure of pneumatic dissection. Best spectacle-corrected visual acuity (BSCVA), corneal tomographic parameters and endothelial cell count were recorded 1, 3, 6, 12 and 24 months after surgery. Densitometric analysis of the deep corneal interface was obtained using Scheimpflug tomography at each visit; values recorded were compared between the two groups and statistically analysed.

Results BSCVA was significantly better in the BB-DALK group than the VB-DALK group (0.39±0.29 vs 0.65±0.23 logarithm of the minimum angle of resolution, respectively) for the first 3 months; and in the same time period, densitometry was significantly higher in the VB-DALK group than those recorded in the BB-DALK group (23.97±5.34 vs 17.13±4.44 grayscale units). However, densitometric values and visual acuity did not differ significantly in the two groups at 1 year. No statistically significant difference for the other variables analysed at any time frame was found.

Conclusion The use of viscoelastic substance in the VB-DALK technique may induce modification of interface stromal reflectivity resulting in reduced visual acuity up to 3 months postoperatively. However, this initial negative effect on the interface quality does not affect the long-term visual outcome, with densitometric values and visual outcomes similar in the two groups from 6 months postoperatively.

  • cornea
  • rehabilitation
  • treatment surgery

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  • Contributors Concept and design of the study: VS, AL and MB. Data acquisition: MB, VDL and DB. Data analysis/interpretation: VS, JM and MS. Drafting the manuscript: VS, JM and MB. Critical revision of manuscript: VS, VDL and AL. Statistical analysis: MS and MB. Final approval: VS, VDL, AL, DB, MB, MS, JM and MB.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval The study protocol was approved by the institutional ethics committee and research was performed according to the tenets of the Declaration of Helsinki.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article or uploaded as supplementary information.

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