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Visual function is reduced in young adults formerly born prematurely: a population-based study
  1. Dýrleif Pétursdóttir,
  2. Gerd Holmström,
  3. Eva Larsson
  1. Institution of Neuroscience/Ophthalmology, Uppsala University, Uppsala, Sweden
  1. Correspondence to Dr Eva Larsson, Ophthalmology, Institution of Neuroscience, Uppsala SE 75185, Sweden; eva.larsson{at}neuro.uu.se

Abstract

Aims To assess visual function in young adults born preterm and compare with full-term individuals of the same age.

Methods Young adults, born preterm (birth weight ≤1500 g) in 1988–1990, previously included in a population-based study on the incidence of retinopathy of prematurity (ROP) in Stockholm County, Sweden were included. A control group of participants born at term, in the same area during the same time period, was used for comparison. Best-corrected visual acuities were assessed at distance and near with logMAR charts. Distance visual acuity was also measured with single symbols to calculate crowding. Visual fields were measured with Humphrey 24-2 and the mean deviation was noted. Contrast sensitivity was assessed with Vistech contrast sensitivity test and the area under the curve was calculated.

Results Fifty-nine preterm (females 37) and 44 full-term (females 18) individuals were included. All individuals were between 25 and 29 years of age. Preterm individuals had significantly lower distance visual acuity (mean −0.08 (SD 0.11) vs −0.14 (SD 0.07) logMAR, p=0.009), near visual acuity (mean −0.08 (SD 0.11) vs −0.13 (SD 0.06) logMAR, p=0.049), mean deviation (mean −1.09 (SD 1.13) vs −0.80 (SD 1.03) dB, p=0.05) and contrast sensitivity (mean 2.02 (SD 0.19) vs 2.16 (SD 0.14), p<0.001) in the better eye compared with full-term individuals. The differences in distance visual acuity and contrast sensitivity were also evident after excluding persons with previous ROP and neurological complications. In multivariable analyses, treated ROP was a risk factor for reduced near visual acuity and visual fields.

Conclusion Visual function seems to be reduced in prematurely born individuals even in adulthood. The reason may be prematurity per se since individuals without previous ROP or neurological complications are also affected.

Synopsis Visual function, assessed as visual acuity, visual fields and contrast sensitivity, was reduced in young adults born preterm and previously included in a population-based study on the incidence of retinopathy of prematurity, as compared with controls.

  • long-term follow-up
  • prematurely born
  • retinopathy of prematurity (rop
  • visual function
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Footnotes

  • Contributors The corresponding author attests that all listed authors meet authorship criteria and that no others meeting the criteria have been omitted. EL and GH contributed to the planning, conduct and reporting, and DP contributed to the conduct and reporting of the work described in the article.

  • Funding The study was funded by the Crown Princess Margaretha Foundation for the Visually Impaired, The Carmen and Bertil Regnér Foundation, Synskadades Vänner i Uppsala län and Ögonfonden.

  • Disclaimer The funders had not been involved in the study design; in the collection, analysis and interpretation of the data; in the writing of the report; and in the decision to submit the paper for publication.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Ethics approval This study was performed in accordance with the ethical standards of the institutional and national research committee and with the Helsinki declaration. The study was approved by the Regional Ethical Review Board in Uppsala, Sweden (no. 2014/548).

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available on request.

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