Aims Corvis ST (CST) yields biomechanical corrected IOP (bIOP) which is purported to be less dependent on biomechanical properties. In our accompanied paper, it was suggested that the repeatability of bIOP is high. The purpose of the current study was to assess the relationship between intraocular pressure (IOP) measured with CST and central corneal thickness (CCT) and corneal hysteresis (CH), in comparison with IOP measured with Goldmann applanation tonometry (GAT) and the ocular response analyzer (ORA).
Methods A total of 141 eyes from 141 subjects (35 healthy eyes and 106 glaucomatous eyes) underwent IOP measurements with GAT, CST and ORA. The relationships between IOP measurements (ORA-IOPg, ORA-IOPcc, CST-bIOP and GAT IOP) and biomechanical properties (CCT, CH and corneal resistance factor (CRF)) were analysed using the linear regression analysis.
Results IOPg, IOPcc and GAT IOP were significantly associated with CCT (p<0.001), whereas bIOP was not significantly associated with CCT (p=0.19). IOPg, bIOP and GAT IOP were significantly associated with CH (IOPg: p<0.001; bIOP: p<0.001; GAT IOP: p=0.0054), whereas IOPcc was not significantly associated with CH (p=0.18). All of IOP records were associated with CRF (p<0.001).
Conclusion The bIOP measurement from CST is independent from CCT, but dependent on CH and CRF.
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Contributors MM, HM, SN, YK and RA contributed to the conception or design of the work. MM, YF, MY, YN and KT contributed to the acquisition of the data for work. MM, HM and RA contributed to the analysis of the data for work. MM and RA contributed to the drafting the work. All authors contributed to the final approval of the version published.
Funding This study was Supported in part by 17K11418 from the Ministry 24 of Education, Culture, Sports, Science, and Technology of Japan and 25 Japan Science and Technology Agency (JST) CREST JPMJCR1304.
Competing interests None declared.
Patient consent for publication Obtained.
Ethics approval The study was approved by the Research Ethics Committee of the Graduate School of Medicine and Faculty of Medicine at The University of Tokyo. This study was performed according to the tenets of the Declaration of Helsinki.
Provenance and peer review Not commissioned; externally peer reviewed.