Background/aim We previously reported the benefit of applying binomial pointwise linear regression (PLR: binomial PLR) to detect 10–2 glaucomatous visual field (VF) progression. The purpose of the current study was to validate the usefulness of the binomial PLR to detect glaucomatous VF progression in the central 24°.
Methods Series of 15 VFs (Humphrey Field Analyzer 24–2 SITA-standard) from 341 eyes of 233 patients, obtained over 7.9±2.1 years (mean±SD), were investigated. PLR was performed by regressing the total deviation of all test points. VF progression was determined from the VF test points analyses using the binomial test (one side, p<0.025). The time needed to detect VF progression was compared across the binomial PLR, permutation analysis of PLR (PoPLR) and mean total deviation (mTD) trend analysis.
Results The binomial PLR was comparable with PoPLR and mTD trend analyses in the positive predictive value (0.18–0.87), the negative predictive value (0.89–0.95) and the false positive rate (0.057–0.35) to evaluate glaucomatous VF progression. The time to classify progression with binomial PLR (5.8±2.8 years) was significantly shorter than those with mTD trend analysis (6.7±2.8 years) and PoPLR (6.6±2.7 years).
Conclusions The binomial PLR method, which detected glaucomatous VF progression in the central 24° significantly earlier than PoPLR and mTD trend analyses, shows promise for improving our ability to detect visual field progression for clinical management of glaucoma and in clinical trials of new glaucoma therapies.
- field of vision
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Contributors Substantial contributions to the conception or design of the work: SA, HM and RA. Acquisition, analysis or interpretation of data for the work: SA, HM, MM, YF, AM, MT, SM, KM, KS, TY, KK, NS, LMZ and RA. Drafting the work or revising it critically for important intellectual content: SA, HM, MM, YF, AM, MT, SM, KM, KS, TY, KK, NS, LMZ and RA. Final approval of the version to be published: SA, HM, MM, YF, AM, MT, SM, KM, KS, TY, KK, NS, LMZ and RA. Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved: SA, HM, MM, YF, AM, MT, SM, KM, KS, TY, KK, NS, LMZ and RA.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Not required.
Ethics approval This retrospective study was approved by the review board of each institute.
Provenance and peer review Not commissioned; externally peer reviewed.
Data availability statement All data relevant to the study are included in the article or uploaded as supplementary information.