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Highlights from this issue
  1. Keith Barton1,
  2. James Chodosh2,
  3. Jost B Jonas, Editors in chief3
  1. 1 Moorfields Eye Hospital, London, London, UK
  2. 2 Ophthalmology, Massachusetts Eye and Ear Infirmary Howe Laboratory Harvard Medical School 243 Charles Street Boston, MA 02114, Boston, Massachusetts, USA
  3. 3 Ruprecht-Karls-University Heidelberg, Seegartenklinik Heidelberg, Department of Ophthalmology, Mannheim, Germany
  1. Correspondence to Keith Barton, Moorfields Eye Hospital, London, London, UK; BJO{at}

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Altered ellipsoid zone reflectivity and deep capillary plexus rarefaction correlate with progression in best disease (see page 461)

Patients in the vitelliform stage of Best disease show significant ellipsoid zone and vascular alterations at deep capillary plexus. The severity of this neurovascular damage significantly correlates with the visual function and may serve as biomarker of more rapid disease progression.

The role of Müller cells in tractional macular disorders: an optical coherence tomography study and physical model of mechanical force transmission (see page 466)

Parafoveal Müller cells guarantee structural stability. Mechanical forces may result in parafoveal Müller cells taking on a vertical orientation. In this configuration, the tension is higher and the cell may transmit significant stress to photoreceptors, potentially affecting vision.

Foveal avascular zone morphology and parafoveal capillary perfusion in sickle cell retinopathy (see page 473)

The application of normative-based parafoveal capillary density deviation mapping in patients with Sickle Cell Retinopathy (SCR) shows promise for immediate qualitative and quantitative assessments of SCR, which may prove useful for clinical management.

Characterisation of microvascular abnormalities using OCT angiography in patients with biallelic variants in USH2A and MYO7A (see page 480)

OCT angiography detected decreased capillary density in retinal plexuses of USH2A and MYO7A patients. Choriocapillaris defects were detected in MYO7A but not USH2A. Decreased vessel density was associated with abnormal macular sensitivity and ellipsoid zone loss.

The estimated healthcare cost of diabetic retinopathy in Indonesia and its projection for 2025 (see page 487)

There is substantial economic burden, nearly 2% of national budget, due to diabetic retinopathy in Indonesia in 2017 which …

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