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Longitudinal changes in the ganglion cell-inner plexiform layer thickness in high myopia: a prospective observational study
  1. Min Woo Lee1,2,
  2. Ki Yup Nam3,
  3. Hye Jin Park1,
  4. Hyung-Bin Lim1,
  5. Jung-Yeul Kim1
  1. 1 Department of Ophthalmology, Chungnam National University Hospital, Daejeon, Korea
  2. 2 Department of Ophthalmology, Konyang University College of Medicine, Daejeon, Korea
  3. 3 Department of Ophthalmology, Gyeongsang National University Changwon Hospital, Changwon, Korea
  1. Correspondence to Professor Jung-Yeul Kim, Department of Ophthalmology, Chungnam National University Hospital, Daejeon 301-721, Korea; kimjy{at}


Aim To determine longitudinal changes of the ganglion cell-inner plexiform layer (GC-IPL) thickness in patients with high myopia.

Methods The subjects were divided into two groups: a high myopia group (axial length ≥26.0 mm) and a normal control group. Both groups were divided into subgroups based on age (decade): 20s, 30s, 40s and 50s. Twenty eyes were included in each subgroup. After the initial visit, GC-IPL thicknesses were measured three more times with at least a 1-year interval between examinations using spectral domain optical coherence tomography. The average GC-IPL thickness was fitted with linear mixed models.

Results The average GC-IPL thickness at the first visit was 78.50 ± 8.79 µm and 84.29 ± 6.12 µm in the high myopia and control groups, respectively. In both groups, the average GC-IPL thickness showed a significant change over time. The rate of GC-IPL reduction in individuals aged in their 50s, 40s, 30s and 20s with high myopia were −0.81 µm/year,–0.51 µm/year, −0.28 µm/year and −0.12 µm/year, respectively, and in controls in their 50s, 40s, 30s and 20s, they were −0.31 µm/year,–0.25 µm/year, −0.12 µm/year and −0.02 µm/year, respectively. Additionally, individuals aged in their 50s showed a statistically significant interaction between group and duration (p<0.001).

Conclusions Highly myopic eyes had thinner GC-IPL and a significantly greater reduction in GC-IPL over 3 years when compared with normal eyes. Additionally, the reduction rate of the GC-IPL thickness was greater in older patients in both groups, which was more prominent in the high myopia group.

  • high myopia
  • ganglion cell-inner plexiform layer
  • spectral domain optical coherence tomography

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  • Contributors Design and conduct of the study (MWL, J-YK); Collection of data (MWL, HJP, J-YK); Analysis and interpretation of data (MWL, KYN, H-BL, J-YK); Writing the article (MWL, J-YK); Critical revision of the article (MWL, J-YK); Final approval of the article (MWL, KYN, H-BL, HJP, J-YK).

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval Institutional Review Board of Chungnam National University Hospital, Daejeon, Republic of Korea.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement No data are available.