Aim To compare retinal ganglion cell (RGC)-related layer thickness asymmetry between early open-angle glaucoma (EG) eyes with superior and inferior hemiretina damage.
Methods This was a retrospective study including 95 EG eyes (mean deviation >−2 dB, including 43 preperimetric glaucoma eyes) with photographically determined glaucomatous retinal nerve fibre layer defect and disc change confined to one hemiretina, and 93 age, sex and refraction matched normal subjects as controls. Ganglion cell complex, ganglion cell layer+inner plexiform layer and circumpapillary retinal nerve fibre layer thickness measured by spectral domain optical coherence imaging were compared between the affected and unaffected hemiretinae within each glaucoma eye as well as to those of the corresponding hemiretina of normal control eyes.
Results Intraeye comparison revealed that there was no significant difference in all parameters between the affected and unaffected hemiretinae in eyes with superior hemiretina damage (p=0.110~0.343) while all parameters were thinner in the affected inferior hemiretina compared with the unaffected superior hemiretina in eyes with inferior hemiretina damage (p<0.001). The affected hemiretina of both groups were thinner compared with normal controls (p<0.001). All parameters of the unaffected hemiretina of eyes with superior hemiretina damage were thinner than normal controls (p<0.001), while eyes with inferior hemiretina damage showed no significant difference compared with those of their corresponding hemiretina of normal eyes (p=0.086~0.924).
Conclusion The pattern of RGC damage in early stage glaucoma may differ depending on which horizontal hemiretina is affected first.
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Contributors All authors contributed to the study concept and design, acquisition, analysis or interpretation of data and critical revision of the manuscript for important intellectual content. HS and AI contributed in acquiring data. HS and MA drafted the manuscript. HS conducted the statistical analysis.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests HS has received lecture fees from Pfizer, Santen, Otsuka and Kowa. AI has received lecture fees from Alcon, Pfizer, Carl Zeiss Meditec, Heidelberg Engineering, Kowa, Otsuka, Santen, Topcon Medical System. MA was a paid member of the advisory board for Topcon Inc, but none of the authors has a proprietary interest in any products described in the article. MA has also received lecture fees from Pfizer, Santen, Kowa, Senju, Aerie, Heidelberg Engineering, Topcon, Alcon, Kowa, Otsuka, and Heidelberg Engineering.
Patient consent for publication Obtained
Ethics approval Ethics Committee of Kanto Central Hospital of the Mutual Aid Association of Public School Teachers ID: 25-1-008. The study adhered to the tenets of the Declaration of Helsinki.
Provenance and peer review Not commissioned; externally peer reviewed.
Data availability statement Data are available upon request.