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Comparison of vascular–function and structure–function correlations in glaucomatous eyes with high myopia
  1. Seung Hyen Lee1,
  2. Eun Ji Lee2,
  3. Tae-Woo Kim2
  1. 1 Department of Ophthalmology, Bundang Jesaeng General Hospital, Daejin Medical Center, Gyeonggi-do, Korea (the Republic of)
  2. 2 Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea (the Republic of)
  1. Correspondence to Dr Eun Ji Lee, Ophthalmology, Seoul National University Bundang Hospital, Seongnam 463-707, Korea (the Republic of); opticdisc{at}


Background/aims To determine the usefulness of peripapillary retinal vessel density (VD) measured using optical coherence tomography (OCT) angiography (OCTA) in the evaluation of glaucomatous visual field damage in highly myopic eyes with primary open-angle glaucoma (POAG).

Methods This cross-sectional observational study enrolled a total of 124 myopic POAG eyes consisting of 40 eyes showing a segmentation error (SE) in OCT scans and 84 eyes without an SE. The peripapillary retinal VD, circumpapillary retinal nerve fibre layer thickness (RNFLT) and visual field sensitivity loss (VFSL) were assessed using OCTA, spectral-domain OCT and standard automated perimetry, respectively. The topographical correlations between the VD and VFSL, and between the RNFLT and VFSL were determined in subgroups divided according to the presence of an SE.

Results The peripapillary retinal VD showed significant topographical correlation with VFSL both in the highly myopic POAG eyes without an SE globally (R=0.527, p<0.001), and in temporal (R=0.593), temporal-superior (R=0.543), nasal-inferior (R=0.422) and temporal-inferior sectors (R=0.600, all p<0.001), and in those with an SE globally (R=0.343, p=0.030), and in temporal (R=0.494, p=0.001), temporal-superior (R=0.598, p<0.001), and temporal-inferior sectors (R=0.424, p=0.006). The correlation with VFSL did not differ between the VD and RNFLT in the eyes without an SE

Conclusion Peripapillary VD as measured with OCTA showed a topographical correlation with VFSL in highly myopic POAG eyes regardless of the presence of an OCT SE OCTA may be a useful adjunct for evaluating glaucomatous visual field damage in high myopia, where the OCT results are frequently confounding.

  • Glaucoma
  • Optic Nerve
  • Imaging

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  • Correction notice The third author's affiliation has been corrected since this paper was published Online First. Tae-Woo Kim's affiliation is Seoul National University Bundang Hospital.

  • Contributors Study concept and design: all authors. Acquisition, analysis or interpretation of data: all authors. Drafting of the manuscript: SHL and EJL. Critical revision of the manuscript for important intellectual content: all authors. Statistical analysis: SHL.

  • Funding This work was supported by Seoul National University Bundang Hospital Research Fund (no. 02-2016-045), Seongnam, Korea.

  • Disclaimer The funding organisation had played no role in the design or conduct of this research.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval This study was approved by the Institutional Review Board of Seoul National University Bundang Hospital, and it conformed to the tenets of the Declaration of Helsinki.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available on request.

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