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Prevalence and clinical features of systemic diseases in Chinese patients with uveitis
  1. Peizeng Yang1,
  2. Zhenyu Zhong1,
  3. Liping Du2,
  4. Fuzhen Li2,
  5. Zhijun Chen1,
  6. Ying Zhu1,
  7. Wanyun Zhang1,
  8. Fanfan Huang1,
  9. Xingsheng Ye1,
  10. Guannan Su1,
  11. Aize Kijlstra3
  1. 1 The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, China
  2. 2 The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Zhengzhou, China
  3. 3 University Eye Clinic Maastricht, Maastricht, The Netherlands
  1. Correspondence to Dr Peizeng Yang, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; peizengycmu{at}


Purpose Systemic diseases are frequently associated with uveitis but are often not recognised by clinicians. An estimate of the prevalence in a large-scale uveitis population is essential for understanding the epidemiological profile and may be helpful for clinical practice.

Design A nationwide survey.

Methods Data were obtained from a national database which included the registration of uveitis cases from 23 provinces, 5 autonomous regions and 4 municipalities across mainland China. The primary outcome was identification of a systemic disease associated with uveitis.

Results From April 2008 through August 2018, 15 373 uveitis patients were included in the study. Males accounted for 52.9%, and the mean (SD) age of uveitis onset was 35.4 (15.9) years. After standardisation for age, the prevalence of systemic disease among patients with uveitis was 30.8% (95% CI, 30.1% to 31.6%). Vogt-Koyanagi-Harada disease (VKH; age-standardised prevalence, 12.7%; 95% CI, 12.1% to 13.2%), Behçet’s disease (BD; 8.7%; 95% CI, 8.3% to 9.2%), ankylosing spondylitis (AS; 5.0%; 95% CI, 4.6% to 5.3%) and juvenile idiopathic arthritis (JIA; 1.2%; 95% CI, 1.0% to 1.3%) were the most common entities among 36 different forms of systemic diseases identified. The prevalence was significantly higher in males (37.0%; 95% CI, 36.0% to 38.1%) than in females (23.6%; 95% CI, 22.6% to 24.6%), and also higher in bilateral uveitis patients (41.2%; 95% CI, 40.2% to 42.2%) compared with unilateral cases (14.3%; 95% CI, 13.4% to 15.2%), and was highest in panuveitis (59.5%; 95% CI, 58.2% to 60.8%).

Conclusion Approximately one third of uveitis patients in this nationwide survey have an associated systemic disease, whereby VKH, BD, AS and JIA are the most frequent entities seen in China.

  • epidemiology
  • inflammation

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  • Contributors PY and ZZ conceived and designed the study. ZZ, ZC, YZ, WZ, FH, XY, GS and FL collected clinical data. ZZ and LD analysed and interpreted the data. PY and ZZ wrote the first draft of the paper. KA reviewed data analysis and provided editorial assistance. PY supervised the study. All authors provided a final review and approved the manuscript before submission.

  • Funding This study was supported by Natural Science Foundation Major International (Regional) Joint Research Project (81720108009), Chongqing Key Laboratory of Ophthalmology (CSTC, 2008CA5003), Chongqing Science & Technology Platform and Base Construction Program (cstc2014pt-sy10002), Natural Science Foundation Project of Chongqing (cstc2017shmsA130073) and National Natural Science Foundation Key Program (81930023).

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval This study has been approved by the Institutional Review Board at the First Affiliated Hospital of Chongqing Medical University, which granted the waiver of informed consent given the fact that the analyses were performed retrospectively and all the data extraction was performed without patient identifiers. The procedures of the study were in accordance with Declaration of Helsinki.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement No data are available. No additional unpublished data.

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