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Prevalence, risk factors and management of ocular hypertension or glaucoma in patients with Vogt-Koyanagi-Harada disease
  1. Peizeng Yang1,
  2. Chaokui Wang1,
  3. Guannan Su1,
  4. Su Pan1,
  5. Yang Qin1,
  6. Jun Zhang1,
  7. Qingfeng Cao1,
  8. Zhenyu Zhong1,
  9. Chunjiang Zhou1,
  10. Yao Wang1,
  11. Aize Kijlstra2
  1. 1 The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Lab of Ophthalmology, Chongqing Eye Institute, Chongqing, China
  2. 2 University Eye Clinic Maastricht, Maastricht, The Netherlands
  1. Correspondence to Peizeng Yang, The First Affiliated Hospital of Chongqing Medical University, Youyi Road 1, Chongqing 400016, China;peizengycmu{at}


Background/aims This study was performed to examine the prevalence, risk factors and treatment outcome of OHT/glaucoma in Chinese patients with Vogt-Koyanagi-Harada (VKH).

Methods Retrospective non-interventional case series were conducted on a total of 2281 patients with VKH referred from April 2008 to April 2019. Of these cases, 1457 had a minimum follow-up period of 3 months and were included for this study. Medical records were reviewed for demographic, ocular and treatment data.

Results Among 2914 eyes of 1457 patients with VKH, 695 (23.9%) eyes of 425 patients (29.2%) developed OHT/glaucoma. The risk factors of OHT/glaucoma included initial BCVA of 20/200 or worse (OR=4.826), final best-corrected visual acuity (BCVA) of 20/50–20/100 (OR=5.341) and final BCVA of 20/200 or worse (OR=4.235), the interval between uveitis attack and referral time interval being 2 months or more (OR=3.318), more than three recurrent episodes (OR=4.177) and posterior synechiae (OR=1.785). The main possible mechanisms of OHT/glaucoma were inflammatory factor-induced open-angle OHT/glaucoma in 277 eyes (39.9%) and pupillary block arising from complete posterior synechiae in 201 eyes (28.9%). In these 695 eyes with OHT/glaucoma, normalised intraocular pressure (IOP) was achieved in 389 eyes (56.0%) following medical treatment. In the remaining 306 eyes, various surgical interventions were performed and a normalised IOP could be achieved in 249 eyes (81.4%).

Conclusion OHT/glaucoma is a common complication in Chinese patients with VKH. Risk factors of OHT/glaucoma included worse acuity at first and final visits, the longer interval between uveitis attack and referral, more recurrent episodes and posterior synechiae.

  • Glaucoma
  • Epidemiology
  • Intraocular pressure

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  • Contributors PY, CW and GS conceived and designed the study. SP, YQ, JZ, QC, CZ and YW collected the clinical data. CW and ZZ analysed and interpreted the data. PY and CW wrote the initial draft. PY, CW, ZZ and KA revised the manuscript. PY supervised the study. All authors provided a final review and approved the manuscript before submission.

  • Funding This work was supported by Chongqing Outstanding Scientist Project (2019), Chongqing Key Laboratory of Ophthalmology (CSTC, 2008CA5003), Innovation project of Chongqing Science & Technology commission (cstc2017shmsA130073) and Chongqing Science & Technology Platform and Base Construction Program (cstc2014pt-sy10002) and the Chongqing Chief Medical Scientist Project (2018).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article.

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