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Effect of long-term rigid gas-permeable contact lens wear on keratoconus progression
  1. Satoko Araki1,
  2. Shizuka Koh1,2,
  3. Daijiro Kabata3,
  4. Ryota Inoue2,4,
  5. Daichi Morii3,
  6. Naoyuki Maeda1,
  7. Ayumi Shintani3,
  8. Vishal Jhanji5,
  9. Kohji Nishida1
  1. 1 Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
  2. 2 Innovative Visual Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
  3. 3 Medical Statistics, Osaka City University Graduate School of Medicine, Osaka, Japan
  4. 4 SEED Co, Tokyo, Japan
  5. 5 Ophthalmology and Visual Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
  1. Correspondence to Dr Shizuka Koh, Ophthalmology, Osaka University Graduate School of Medicine, Suita 565-0871, Osaka, Japan; cizciz{at}


Background/aims To investigate the chronological corneal changes associated with long-term rigid gas-permeable contact lens (RGP-CL) wear in patients with keratoconus (KC).

Methods Clinical records of 405 patients with KC or with KC suspect were retrospectively reviewed. Patients with mild-to-moderate KC and uneventful follow-up were classified into the CL (RGP-CL wear) and non-CL (without CL wear) groups. Inclusion criteria were (1) at least 3-year follow-up and (2) Scheimpflug-based corneal imaging examination at each visit. The anterior (ARC) and posterior (PRC) radius of curvature obtained in a 3.0 mm optical zone, the thinnest pachymetry reading of the corneal thickness (Tmin), and maximum keratometry values (Kmax) were investigated as tomographic parameters.

Results Twenty-two and 15 patients who met the inclusion criteria were included in the CL and non-CL groups, respectively (31 and 20 eyes, respectively). The mean observation periods were 75 (CL group) and 63 (non-CL group) months. A multivariable non-linear regression analysis to assess the change in tomographic parameters over the follow-up period and difference of the trend between the two groups demonstrated no significant differences in the chronological change in ARC, PRC and Tmin between the CL and non-CL groups (p=0.318, p=0.280 and p=0.874, respectively).

Conclusion Based on corneal tomographic evaluation over 5–6 years, the effects of long-term RGP-CL wear had no effect on KC progression.

  • cornea
  • contact lens

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  • Funding This work was supported by SEED Co.

  • Disclaimer The sponsor had no role in the study design, data collection, analysis and interpretation, in writing of the report and in the decision to submit the article for publication.

  • Competing interests SK and NM received fees from Oculus for a sponsored seminar, not related to this article. RI is an employee of SEED Co. None of the other authors or their family members have any proprietary or financial interests in any of the material or instruments mentioned in this article.

  • Patient consent for publication Not required.

  • Ethics approval This study was reviewed and approved by the institutional review board of the Osaka University Hospital. The study was conducted in accordance with the tenets of the Declaration of Helsinki, as revised in 2013.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available upon reasonable request.

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