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  • Heritability of macular ganglion cell inner plexiform layer thickness as determined by optical coherence tomography: the Healthy Twin Study

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Clinical science
Heritability of macular ganglion cell inner plexiform layer thickness as determined by optical coherence tomography: the Healthy Twin Study
  1. Mingui Kong1,2,
  2. Sungsoon Hwang3,
  3. Hyeonyoung Ko4,
  4. Ga-In Lee3,
  5. Moonil Kang5,
  6. Joohon Sung5,
  7. Yun-Mi Song4,
  8. Don-Il Ham3
  1. 1 Hangil Eye Hospital, Incheon, Korea
  2. 2 Department of Ophthalmology, Catholic Kwandong University College of Medicine, Incheon, Korea
  3. 3 Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
  4. 4 Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
  5. 5 Division of Genome and Health Big Data, Department of Public Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Korea
  1. Correspondence to Yun-Mi Song, Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea; yunmisong{at}skku.edu
  2. Don-Il Ham, Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea;oculus{at}naver.com

Abstract

Purpose To evaluate genetic influence on macular ganglion cell inner plexiform layer (GCIPL) thickness.

Methods Macular GCIPL thickness was measured with optical coherence tomography in nine macular subfields defined by the E TDRS. Intraclass correlation coefficients (ICC) of GCIPL thickness by different types of family relationships were estimated to assess intrafamilial resemblance. Then, heritability of GCIPL thickness was estimated.

Results Three hundred and sixty-one Korean adults from 89 families with normal healthy eyes were included. GCIPL thickness was highest in inner subfields and lowest in fovea. Monozygotic twin pairs showed significantly higher ICCs of GCIPL thickness in all subfields compared to those in parent–offspring pairs and sibling pairs. GCIPL thickness was highly heritable in the centre (0.71) and outer subfields but moderate to highly heritable in inner subfields. Heritability of GCIPL thickness in outer subfields was 0.69, 0.67, 0.72 and 0.68 for superior, inferior, temporal and nasal fields, respectively. Heritability of GCIPL thickness in inner subfields was 0.55, 0.56, 0.75 and 050 for superior, inferior, temporal and nasal subfields, respectively.

Conclusion Macular GCIPL thickness is significantly influenced by genetic factors. It varies according to subfields with moderate to high heritability in all subfields.

  • Genetics

https://doi.org/10.1136/bjophthalmol-2020-316512

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    Footnotes

    • MK and SSH are co-first authors.

    • Correction notice This paper has been corrected since it was published online. The second author's first name has been amended.

    • Contributors Involved in conception and design: Don-Il Ham, Yun-Mi Song; conducted the study: Mingui Kong, Sung Soon Hwang; collection and management, interpretation of data and data analysis: Mingui Kong, Sung Soon Hwang, Hyeonyoung Ko, Ga-In Lee, Moonil Kang; writing the article: Mingui Kong, Sung Soon Hwang, Don-Il Ham, Yun-Mi Song; preparation, review and approval of the manuscript: Mingui Kong, Sung Soon Hwang, Don-Il Ham, Yun-Mi Song.

    • Funding This study was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI#HI14C0064) and a basic science research programme through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (#2012-0004255). The funding organisations had no role in the design or conduct of this research.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Data availability statement Data are available upon reasonable request.

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