Article Text

Download PDFPDF
3-D assessment of gaze-induced eye shape deformations and downgaze-induced vitreous chamber volume increase in highly myopic eyes with staphyloma
  1. Quan V Hoang1,2,
  2. Stanley Chang2,
  3. Daryle Jason Go Yu1,
  4. Lawrence A Yannuzzi3,
  5. K Bailey Freund3,
  6. Jack Grinband4
  1. 1 Singapore Eye Research Institute, Singapore National Eye Centre, Duke National University of Singapore, Singapore
  2. 2 Ophthalmology, Columbia University College of Physicians and Surgeons, New York City, New York, USA
  3. 3 Vitreous Retina Macula Consultants of New York, New York, New York, USA
  4. 4 Radiology, Columbia University College of Physicians and Surgeons, New York City, New York, USA
  1. Correspondence to Quan V Hoang, Singapore Eye Research Institute, Singapore National Eye Centre, Duke-NUS, 20 College Rd, Singapore, Singapore; donny.hoang{at}singhealth.com.sg

Abstract

Purpose To determine if the stress of normal eye movements results in gaze-induced globe deformations, vitreous chamber axial length and vitreous chamber axial volume (VCAV) change in highly myopic eyes.

Methods A prospective imaging study was performed on 82 eyes of 43 patients with high myopia (>27 mm of axial length) with a clinical diagnosis of staphyloma. Three-dimensional MRI scans were acquired while subjects gazed in five directions (primary, nasal, temporal, superior and inferior). Surface renderings were generated, and a processing pipeline was created to automate alignment of the eye and to measure VCAV within 5.5 mm of the visual axis for each eye in every gaze. The degree of gaze-induced globe deformation was determined by calculating the Dice coefficient to assess the degree of overlap of the sclera at each eccentric gaze with that found in primary gaze. Each eccentric gaze VCAV was compared to VCAV in primary gaze using a fixed-effects regression allowing for subject-specific and eye-specific effects.

Results The Dice coefficient showed significant gaze-induced eye shape changes in all gazes (all p<0.0001). There were no statistically significant gaze-induced VCAV changes when comparing primary gaze to nasal, temporal or upgaze. However, when changing from primary to downgaze, VCAV was increased by +4.79 mm3 (p=0.002, 95% CI 1.71 to 7.86).

Conclusion Significant gaze-induced globe deformation was noted in all gazes, but a reversible, instantaneous VCAV increase occurred only in downgaze, which is consistent with studies supporting the association of environmental factors such as near work with myopia development and progression.

  • Eye (Globe)
  • Imaging
  • Retina
  • Sclera and Episclera
  • Vitreous

Statistics from Altmetric.com

Footnotes

  • Contributors Design of the study: QVH, JG. Conduct of the study: QVH, SC, DJGY, LAY, KBF, JG. Collection of the data: QVH, SC, LAY, KBF, JG. Management of the data: QVH, DJGY, JG. Analysis of the data and interpretation of the data: QVH, JG. Preparation of the manuscript: QVH, DJGY, JG. Review of the manuscript and approval of the manuscript: QVH, SC, DJGY, LAY, KBF, JG.

  • Funding This publication was supported in part by Career Development Awards from Research to Prevent Blindness (QVH), K08 Grant (QVH, 1 K08 EY023595, National Eye Institute, NIH) the Louis V. Gerstner Jr Scholars Program (QVH), Clinician Scientist Award (QVH, CSA-INVMay0011, National Medical Research Council, Singapore), philanthropic donation from John Cushman (QVH) and The Macula Foundation, New York, NY (LAY). The funding organisations had no role in the design or conduct of this research.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available upon reasonable request.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles

  • At a glance
    Frank Larkin