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Graft detachments in endothelial keratoplasty
  1. Rashmi Deshmukh1,
  2. Sridevi Nair2,
  3. Darren Shu Jeng Ting3,
  4. Tushar Agarwal2,
  5. Jacqueline Beltz4,
  6. Rasik B Vajpayee4,5,6
  1. 1 Department of Ophthalmology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
  2. 2 Department of Ophthalmology, All India Institute of Medical Sciences Dr RP Centre for Ophthalmic Sciences, New Delhi, India
  3. 3 Academic Ophthalmology, University of Nottingham, Nottingham, Nottinghamshire, UK
  4. 4 Department of Ophthalmology, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
  5. 5 Centre for Eye Research Australia, The University of Melbourne, Melbourne, Victoria, Australia
  6. 6 Department of Ophthalmology, Vision Eye Institute Ltd, Melbourne, Victoria, Australia
  1. Correspondence to Professor Rasik B Vajpayee, Centre for Eye Research Australia, The University of Melbourne, Melbourne, Victoria VIC 3002, Australia; rvajpayee{at}


Graft detachment is the most common complication of endothelial keratoplasty. With the ongoing advancements in the field of endothelial keratoplasty, our understanding of risk factors of graft detachments and its management has been evolving. Various prevention measures have been described in literature including presoaking the donor graft, anterior chamber tamponade, venting incisions, sutures to prevent dislocation of graft. Management of a detached graft involves secondary interventions such as rebubbling, suturing and regrafts. In this review, we discuss graft detachment in different types of endothelial keratoplasty techniques including Descemet stripping endothelial keratoplasty, Descemet stripping automated endothelial keratoplasty and Descemet’s membrane endothelial keratoplasty; with emphasis on incidence, risk factors, preventive measures and their management.

  • cornea
  • treatment surgery

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  • Contributors All authors confirm that they have made substantial contributions to the conception and design of the work;and have helped with the drafting of the work or revising it critically for important intellectual content;and approved the final version to be published.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.