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Clinical science
Dilated choroidal veins and their role in recurrences of myopic macular neovascularisations
  1. Shiqi Xie1,
  2. Ran Du1,
  3. Yuxin Fang1,2,
  4. Yuka Onishi1,
  5. Tae Igarashi1,
  6. Hiroyuki Takahashi1,
  7. Koju Kamoi1,
  8. Kyoko Ohno-Matsui1
  1. 1 Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Bunkyo-ku, Japan
  2. 2 Beijing Ley Laboratory of Ophthalmology and Visual Science, Beijing Tongren Eye Center, Beijing, China
  1. Correspondence to Dr Kyoko Ohno-Matsui, Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Bunkyo-ku 1138510, Japan; k.ohno.oph{at}tmd.ac.jp

Abstract

Aim To determine whether there is a correlation between the presence of macular dilated choroidal vein (DCV) and the recurrence of myopic macular neovascularisation (MNV) after antivascular endothelial growth factor (VEGF) treatment.

Methods Medical records of 168 eyes of 163 patients with myopic MNV were reviewed for the presence of macular DCV and episodes of recurrences. A macular DCV was defined as a choroidal vein whose diameter was 2× larger than the adjacent veins coursing in the macular area of 5.5 mm diameter.

Results Macular DCV existed in 47 (28%) of the eyes with myopic MNV. 70 eyes (41.7%) had recurrence during a mean follow-up period of 52.5±23.0 months. Recurrence was found in 28 of the 47 eyes (59.6%) with DCV, which was significantly more frequent than the 42 of the 121 eyes (34.7%) without DCV (p=0.003). Cox model analysis showed that macular DCV was an independent risk factor (HR: 2.0, 95% CI 1.1 to 3.5) for recurrence. The recurrence rate was significantly higher in eyes with DCV within the first 2 years after the onset than in eyes without DCV.

Conclusions Macular DCVs may be indicators of a more aggressive phenotype of eyes with myopic MNV. These eyes need careful monitoring after anti-VEGF therapies.

  • choroid
  • imaging
  • macula
  • neovascularisation
  • retina

Data availability statement

Data are available upon reasonable request. Our data are patient image data and this study was approved by the Ethics Committee of Tokyo Medical and Dental University. Data can be available if applying for the permission from Ethics Committee upon reasonable request. Contact address: Ophthalmology & Visual Science Tokyo Medical and Dental University 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan 113-8510 TEL 03-3813-6111 FAX 03-3818-7188.

http://dx.doi.org/10.1136/bjophthalmol-2021-318970

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    Data availability statement

    Data are available upon reasonable request. Our data are patient image data and this study was approved by the Ethics Committee of Tokyo Medical and Dental University. Data can be available if applying for the permission from Ethics Committee upon reasonable request. Contact address: Ophthalmology & Visual Science Tokyo Medical and Dental University 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan 113-8510 TEL 03-3813-6111 FAX 03-3818-7188.

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    Footnotes

    • Contributors SX, RD, KO-M contributed to research design, research execution and manuscript preparation. All authors contributed to data acquisition and data analysis and interpretation. KO-M accepts full responsibility for the finished article, had access to any data and controlled the decision to publish.

    • Funding This work was supported by grants from the Japanese Society for Promotion of Science (number 19H03808).

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.

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