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Highlights from this issue
  1. Frank Larkin, Editor in Chief
  1. Moorfields Eye Hospital NHS Foundation Trust, London, UK
  1. Correspondence to Prof Frank Larkin, Moorfields Eye Hospital NHS Foundation Trust, London, EC1V 2PD, UK; f.larkin{at}

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New model to better diagnose dry eye disease integrating OCT corneal epithelial mapping (see page 1488)

Thickness pattern of the epithelium as assessed by wide-field corneal OCT is an accurate biomarker for dry eye, and can be integrated into a multivariable model for an objective screening of the disease.

Visual acuity outcomes after cataract surgery in type 2 diabetes: the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study (see page 1496)

In a cohort of persons with type 2 diabetes, two-thirds of eyes achieved good visual outcome after cataract surgery. Pre-operative visual acuity and presence of diabetic retinopathy have impact on visual acuity outcomes. Though the current visual prognosis after cataract surgery is usually favourable, certain factors still limit the visual potential in those with diabetes and continued efforts to improve visual outcomes are needed

Predicting the 10-year risk of cataract surgery using machine-learning techniques on questionnaire data: findings from the 45 and Up Study (see page 1503)

Machine learning techniques on self-reported questionnaire data can accurately predict the 10 year risk of cataract surgery.

Long-term evaluation of anterior lens density after implantable collamer lens V4c implantation in patients with myopia over 40 years old (see page 1508)

The anterior lens density increased slightly in long term follow-up of myopes over 40 years of age after Implantable Collamer Lens V4c procedures, but no cataract was observed.

Interpretation of change scores for the National Eye Institute Visual Function Questionnaire-25: the minimally important difference (see page 1514)

The National Eye Institute Visual Function Questionnaire-25 is a widely used outcome measure. Interpreting the scores is challenging. A 6-point change in score is likely to be a patient-important difference in early glaucoma.

High rate of conversion from ocular hypertension to glaucoma in subjects with uveitis (see page 1520)

In patients requiring treatment for uveitis-associated ocular hypertension for 3 months or more, glaucoma develops in 77%, with a median time from diagnosis of ocular hypertension to development of glaucoma of 1.2 years.

Novel utilisation of ultrawide-field fundus photography for detecting retinal nerve fibre layer defects in glaucomatous eyes (see page 1524)

The green separation image of non-mydriatic ultrawide-field fundus photography demonstrated high sensitivity and moderate specificity for detecting retinal nerve fibre layer defects, indicating comparable diagnostic performance to conventional red-free photography.

Higher contrast thresholds for vanishing optotype recognition in macular visual fields among glaucoma patients: a structure–function analysis (see page 1530)

In glaucoma patients, there is a higher contrast requirement for vanishing pattern recognition, even among those with normal light sensitivity on standard perimetry, and this is strongly correlated with the thinning of retinal ganglion cell layer.

Implications of COVID-19 infection on patients with uveitis under biologic treatment (see page 1538)

Uveitis patients on biologic therapy can be silent carriers for COVID-19.

Genetic associations of central serous chorioretinopathy: a systematic review and meta-analysis (see page 1542)

In this meta-analysis, the authors summarised all reported genetic associations of central serous chorioretinopathy, and revealed different association patterns among central serous chorioretinopathy, neovascular age-related macular degeneration and polypoidal choroidal vasculopathy

Surveillance of people with previously successfully treated diabetic macular oedema and proliferative diabetic retinopathy by trained ophthalmic graders: cost analysis from the EMERALD study (see page 1549)

Surveillance of patients with previously successfully treated diabetic macular oedema/proliferative diabetic retinopathy can be done by trained ophthalmic graders using multimodal imaging. This releases ophthalmologist time for care of other patients with vision-threatening disease

Long term outcome of neovascular age-related macular degeneration: association between treatment outcome and major risk alleles (see page 1555)

Baseline intraretinal fluid, and follow-up macular atrophy and thinning, were associated with worse functional outcomes in neovascular age-related macular degeneration eyes on treatment. Complement risk allele carriers had less reduction in baseline macular thickness.

Anti-VEGF-resistant subretinal fluid is associated with better vision and reduced risk of macular atrophy (see page 1561)

In a post hoc analysis of ranibizumab-treated eyes in HARBOR, anti-vascular endothelial growth factor-resistant subretinal fluid (SRF) was associated with reduced risk of macular atrophy, regardless of SRF thickness, in comparison to eyes without SRF after treatment.

Three-year results of phase I retinal gene therapy trial for CNGA3-mutated achromatopsia: results of a non-randomised controlled trial (see page 1567)

A subretinal AAV8-mediated gene therapy for CNGA3 mutation Achromatopsia in 9 patients proved to be safe over an observation period of 3 years and informs about the most promising efficacy endpoints for future trials.

Development and validation of a new clinical decision support tool to optimize screening for retinopathy of prematurity (see page 1573)

DIGIROP-Screen, a clinical decision support tool, developed on~7000 infants and externally validated on~1200 infants, may safely reduce the number of ROP screening examinations for 45% of infants at birth and additionally for 25% during the screening course.

Risk factors for ophthalmic artery stenosis and occlusion in retinoblastoma patients treated with intra-arterial chemotherapy (see page 1581)

Initial ophthalmic artery (OA) diameter and number of intra-artery chemotherapy infusions may be predictors of OA stenosis and occlusion after this treatment.

Comparative analysis of immunosuppressive therapies for myelin oligodendrocyte glycoprotein antibody-associated optic neuritis: a cohort study (see page 1587)

Both mycophenolate mofetil and low-dosage rituximab treatment facilitate disease remission in patients with myelin oligodendrocyte glycoprotein antibody-associated optic neuritis. Moreover, patients treated with rituximab have significantly better compliance than with mycophenolate mofetil.

Optic nerve tortuosity and displacements during horizontal eye movements in healthy and highly myopic subjects (see page 1596)

Adjusted optic nerve tortuosity was lower in high myopic eyes, suggesting that eyes destined toward high myopia exhibited higher optic nerve traction forces during eye movements before the onset of myopia.

Phantom vision after eye removal: prevalence, features and related risk factors (see page 1603)

Phantom vision may concern up to one third of the patients undergoing eye removal. It is more likely in patients with high severity scores for anxiety and depression, and those undergoing enucleation.

Association of objective visual impairment with suicidal ideation and suicide attempts among adults aged ≥50 years in low/middle-income countries (see page 1610)

In a sample of 34 129 older adults from low-and middle-income countries, moderate and severe visual impairment was significantly associated with greater odds of suicidal ideation and suicide attempts

Preincubation of donor tissue with a VEGF cytokine trap promotes subsequent high-risk corneal transplant survival (see page 1617)

Corneal buttons can serve as a depot for anti-(lymph)angiogenic agents. Preincubating donor tissue with a VEGF-R1R2 cytokine trap can induce graft tolerance and promote experimental graft survival in high-risk keratoplasty.

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  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.

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