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Corneal tomographic changes during corneal rigid gas-permeable contact lens wear in keratoconic eyes
  1. Shizuka Koh1,2,
  2. Ryota Inoue1,3,
  3. Naoyuki Maeda2,
  4. Yoshinori Oie2,
  5. Vishal Jhanji4,
  6. Atsuya Miki1,2,
  7. Kohji Nishida2
  1. 1 Innovative Visual Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
  2. 2 Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
  3. 3 SEED CO., LTD, Tokyo, Japan
  4. 4 Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
  1. Correspondence to Shizuka Koh, Department of Innovative Visual Science, Osaka University Graduate School of Medicine, Room E7, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan; cizciz{at}


Background/Aims We aimed to investigate the refractive changes in the posterior corneal surface in keratoconus (KC) associated with wearing spherical corneal rigid gas-permeable contact lenses (corneal GPs) with apical touch or three-point touch fitting and the effect of spherical corneal GPs on corneal biomechanics.

Methods Patients with KC wearing corneal GPs every day without facing complications were enrolled as a single group. Corneal tomographic data were obtained using a three-dimensional anterior segment optical coherence tomography from the same eye with and without corneal GPs. Dioptric data from the central 3-mm zone of the posterior corneal surface were decomposed into spherical, regular astigmatism, asymmetry and higher-order irregularity components using Fourier harmonic analysis. The corneal biomechanical indices were deformation amplitude ratio within 2 mm, integrated radius, stiffness parameter at first applanation and linear Corvis Biomechanical Index. Correlations between the difference in Fourier indices with and without corneal GPs and the corneal biomechanical parameters were analysed.

Results Thirty-two eyes of 32 patients with KC were enrolled. Spherical, regular astigmatism and asymmetry components were significantly smaller with corneal GP wear than without the wear (all p<0.001). All biomechanical indices were significantly correlated with the difference in the spherical components with and without corneal GPs.

Conclusion Corneal biomechanical properties of KC were correlated with posterior corneal surface flattening induced by wearing corneal GPs on the spherical components. This effect is greater in biomechanically weaker corneas.

  • Cornea
  • Contact lens

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  • Acknowledgements The authors would like to thank Dr Sven Reisdorf and Ms Stefanie Berger (Oculus Optikgeräte GmbH) for their helpful discussion and calculation.

  • Funding This work was supported by SEED CO., LTD. The sponsor had no role in the study design, data collection, analysis and interpretation, in writing of the report and in the decision to submit the article for publication.

  • Competing interests SK received fees from Oculus (Wetzlar, Germany) for a sponsored seminar, which was not related to this study. RI is an employee of SEED CO., LTD. (Tokyo, Japan). None of the other authors or their family members have any proprietary or financial interests in any of the material or instruments mentioned in this article.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available upon reasonable request.

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