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Highlights from this issue
  1. Frank Larkin, Editor in Chief
  1. Moorfields Eye Hospital NHS Foundation Trust, London, UK
  1. Correspondence to Dr Frank Larkin, Moorfields Eye Hospital, London EC1V 2PD, UK; f.larkin{at}

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Teprotumumab reduces extraocular muscle and orbital fat volume in thyroid eye disease (see page 165)

Teprotumumab reduces orbital muscle and fat volumes, which correlates to its clinical effect of proptosis and diplopia reduction in patients with active thyroid eye disease.

Association between corneal refractive surgery and the prevalence of glaucoma: Korea National health and nutrition examination survey 2010-2012 (see page 172)

This population-based cross-sectional study showed that history of corneal refractive surgery was associated with the prevalence of glaucoma in Korea, although the significance may have been influenced by preoperative refractive status.

Eye bank versus surgeon prepared DMEK tissues: influence on adhesion and re-bubbling rate (see page 177)

Eye bank-prepared DMEK grafts were associated with decreased adhesion forces in an ex vivo study and higher re-bubbling rate in a clinical comparative study.

A new storage medium containing amphotericin B vs Optisol-GS for preservation of human donor corneas (see page 184)

The new cold corneal storage media containing amphotericin B preserved qualitative characteristics of donor cornea intended for transplantation similarly to Optisol-GS after 14 days of storage under hypothermic conditions.

Safety and tolerability of topical polyhexamethylene biguanide (PHMB): a randomised clinical trial in healthy adult volunteers (see page 190)

PHMB 0.02% is unlicensed but used for treating acanthamoeba keratitis (AK). This study shows that higher concentrations of PHMB (0.04% to 0.08%) are safe in normal eyes justifying their use in AK treatment trials.

Corneal tomographic changes during corneal rigid gas-permeable contact lens wear in keratoconic eyes (see page 197)

In keratoconus, rigid gas-permeable contact lens wear with apical corneal touch or three-point touch fitting corrects the posterior spherical component and corneal regular/irregular astigmatism due to biomechanical stress-strain.

Endothelial keratoplasty with anterior chamber intraocular lens versus secondary posterior chamber intraocular lens (see page 203)

In cases of pseudophakic or aphakic corneal oedema, a secondary posterior chamber intraocular lens confers a more favourable long-term graft survival outcome than anterior chamber lens in Descemet’s stripping automated endothelial keratoplasty.

Immediate versus delayed sequential bilateral cataract surgery in children: a cost-effectiveness analysis (see page 211)

Immediate sequential bilateral cataract surgery (ISBCS) is equally effective and less costly than delayed sequential bilateral cataract surgery (DSBCS) from a societal and health care provider perspective for the treatment of children with bilateral cataracts.

What do patients with glaucoma see: a novel IpaD APP to improve glaucoma patient awareness of visual field loss (see page 218)

Almost half of glaucoma patients are unaware of their visual field defects. We have designed and tested an iPad app to help patients pictorialise their field defects.

Optic nerve head vessel density in different stages of pseudoexfoliation disease (see page 223)

Capillary density dropout can be detected in non-glaucomatous fellow eyes of pseudoexfoliative glaucoma patients at comparable retinal fibre layer thickness and can be helpful for earlier detection of glaucomatous change in pseudoexfoliation.

Relationship between mean follow-up intraocular pressure, rates of visual field progression, and current target intraocular pressure guidelines (see page 229)

Patients with manifest glaucoma experienced slower rates of visual field progression when the mean intraocular pressure during follow up remained within the guidelines-driven targets, regardless of the stage of the disease.

Evaluation of fluocinolone acetonide 0.19 mg intravitreal implant in the management of birdshot retinochoroiditis (see page 234)

In a retrospective study to examine therapeutic action of intravitreal fluocinolone in retinal and choroidal inflammation in patients with birdshot retinochoroiditis, our findings suggest retinal improvement but persistent choroidal inflammation.

Disorganisation of retinal inner layers is associated with reduced contrast sensitivity in retinal vein occlusion (see page 241)

Disorganisation of the retinal inner layers (DRIL) was associated with reduced contrast sensitivity in eyes with macular oedema secondary to retinal vein occlusion in a prospective, observational cohort study of 58 visits from 31 patients.

Aflibercept for age-related macular degeneration: four-year outcomes of a treat-and extend regimen with exit criteria (see page 246)

Patients with neovascular age related macular degeneration treated with a Treat-and-extend regimen with exit criteria, without an initial loading phase, are likely to maintain and improve their vision over a four-year treatment period.

Longitudinal assessment of quantitative ultra-widefield ischaemic and vascular parameters in sickle cell retinopathy (see page 251)

Progression in sickle cell retinopathy was evaluated using ischaemia index, vascular area, and vascular length. All parameters demonstrated statistically significant progression. Ischaemic index increased more in eyes with advanced baseline stage and longer follow-up.

Inner retinal thickening affects microperimetry thresholds in the presence of photoreceptor thinning in patients with RPGR X-linked retinitis pigmentosa (see page 256)

In this retrospective study in a cohort of patients with RPGR X-linked RP, we found inner retinal thickening is associated with photoreceptor thinning. The inner retinal thickening has an impact on microperimetry threshold.

Clinical predictive factors for diagnosis of MOG-IgG and AQP4-IgG related paediatric optic neuritis: a Chinese cohort study (see page 262)

When glial autoantibody status is unavailable, multiple clinical parameters increased the sensitivity and specificity in diagnosis of paediatric MOG and AQP4 immunoglobin-associated optic neuritis.

Machine learning to determine relative contribution of modifiable and non-modifiable risk factors of major eye diseases (see page 267)

We identified using machine learning the main determinants of the major eye disease among clinical, metabolic, genetic, lifestyle and socio-economic factors. We found that modifiable risk factors had the highest contributions for glaucoma and retinopathy.

Visual impairment in rural and migrant Chinese school-going children: prevalence, severity, correction, and associations (see page 275)

An analysis of twelve Chinese cohorts (n=83 273) found visual impairment in 32.8% of children aged 6–17 years. Only 35.9% of children who needed glasses were in possession of them. The population’s unmet need for glasses peaked in junior high school, at 31.8%.

Autosomal recessive congenital hereditary corneal dystrophy associated with a novel SLC4A11 mutation in two consanguineous Tunisian families (see page 281)

First clinical and genetic study of Autosomal recessive corneal endothelial dystrophy (CHED) in two Tunisian families and identification of a novel non-frameshift deletion mutation DelLeu 479. This work may lead to a better understanding of CHED pathophysiology.

Evaluation of intravitreal topotecan dose levels, toxicity, and efficacy for retinoblastoma vitreous seeds: a preclinical and clinical study (see page 288)

Using our rabbit model to study intravitreal topotecan for retinoblastoma vitreous seeds, we determine the pharmacokinetics and effective dose of intravitreal topotecan, demonstrating its efficacy and absence of toxicity compared with melphalan. This is corroborated by our retinoblastoma patient data comparing topotecan to melphalan.

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.

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