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Effects of taking pregabalin (Lyrica) on the severity of dry eye, corneal sensitivity and pain after laser epithelial keratomileusis surgery
  1. Dong Won Paik1,
  2. Dong Hui Lim1,2,
  3. Tae-Young Chung1
  1. 1 Department of Ophthalmology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea (the Republic of)
  2. 2 Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Seoul, Korea (the Republic of)
  1. Correspondence to Dr Tae-Young Chung, Ophthalmology, Samsung Medical Center, Seoul, Gangnam-gu, Korea (the Republic of); tychung{at}


Background Corneal nerve damage after laser epithelial keratomileusis (LASEK) is thought to be the cause of dry eye and pain. Therefore, we investigated whether taking pregabalin (Lyrica), which reduces peripheral neuropathic pain, alleviates corneal nerve sensitivity after surgery and reduces dry eye and pain.

Methods Patients were treated with pregabalin (150 mg two times a day for 15 days) from the day before surgery onward and compared with those who did not receive the medications. Before surgery, the severity of dry eye was assessed. Then, corneal sensitivity was assessed by esthesiometry and pain was assessed according to the Visual Analogue Scale. Images of the sub-basal nerve plexus were analysed using confocal microscopy to evaluate nerve regeneration at 6 months.

Results Forty eyes in the pregabalin group and 40 eyes in the control group were included in this study. No significant differences regarding the severity of dry eye, corneal sensitivity test results and nerve fibre density existed between the two groups until 6 months. The pregabalin group showed significantly reduced pain at 1 week.

Conclusions Taking pregabalin during LASEK surgery may affect corneal nerve sensitivity and reduce pain. However, for up to 6 months thereafter, corneal sensitivity and nerve fibre density are not significantly different from findings in the control group, so pregabalin does not seem to affect nerve regeneration or structural changes.

  • pregabalin
  • pain
  • dry eye
  • corneal sensitivity
  • nerve regeneration

Data availability statement

No data are available.

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  • DWP and DHL contributed equally.

  • Presented at Presented in part at the 2019 Annual Meeting of the ASCRS, San Diego, USA, April 2019.

  • Author Contributions DWP wrote the initial draft of the manuscript. DWP and DHL. conceived the concept for this study. DHL and T-YC were involved in critical revision of the manuscript. DWP and DHL performed the statistical analysis. T-YC and DHL supervised the study. DWP and DHL contributed equally to the work as cofirst authors.

  • Funding This work was supported by a grant of National Research Foundation of Korea grant funded by the Korean government’s Ministry of Education (NRF-2020R1A2C2014139; Seoul, Korea) which was received by T-YC.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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