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Clinical course and treatment of archipelago keratitis: a Herpesviridae keratitis subtype
  1. Damien Guindolet1,
  2. Anna Gemahling1,
  3. Antoine Rousseau2,3,
  4. Pauline Nguyen Kim1,
  5. Georges Azar1,
  6. Gilles C Martin1,
  7. Isabelle Cochereau1,4,5,
  8. Marc Labetoulle2,3,
  9. Eric E Gabison1,4,5
  1. 1 Department of Ophthalmology – Pr Cochereau, Hôpital Fondation Ophtalmologique Adolphe de Rothschild, Paris, France
  2. 2 Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT). IDMIT Infrastructure. CEA, Université Paris-Saclay, Inserm U1184, 18 route du Panorama, 92265, Cedex, Fontenay-aux-Roses, France
  3. 3 Department of Ophthalmology, Bicêtre Hospital, APHP, Paris-Saclay University, Le Kremlin-Bicêtre, France
  4. 4 Université Paris Cité, Paris, France
  5. 5 Department of Ophthalmology, Bichat Claude-Bernard Hospital, Paris, France
  1. Correspondence to Professor Eric E Gabison, Corneal and External Diseases, Fondation Ophtalmologique Adolphe de Rothschild, Paris 75019, France; egabison{at}


Purpose Archipelago keratitis (ApK) is a subtype of Herpesviridae stromal keratitis that consists of subepithelial nummular inflammatory infiltrates arranged in a radial centripetal pattern. This rare and poorly described form is not often recognised early. We report the first large series of ApK, with an analysis of clinical settings at presentation, evolution of the disease with time and a description of factors associated with recurrence.

Methods The clinical records of 82 patients (83 eyes) with a diagnosis of ApK between 2011 and 2021 in two centres were reviewed.

Results The median age of the 82 patients at referral was 37±28 years. ApK was unilateral in all but one case. A total of 76% of patients had at least one second diagnostic criteria suggesting a herpetic aetiology. Overall, 44 (53%) eyes exhibited least one recurrence after a median of 12 months. Recurrence was frequently associated with neovascularisation (HR 2.1, 95% CI 1.1 to 3.9; p=0.02) and tapering corticosteroids (HR 3.5, 95% CI 1.8 to 7.1; p<0.01) or valaciclovir use (HR=2.3, 95% CI 1.2 to 4.6; p=0.01). Antiviral treatment was used in all patients, whereas local anti-inflammatory drugs such as corticosteroids and/or ciclosporin were used in 73 (88%) cases.

Conclusion ApK is a Herpesviridae stromal keratitis that is typically unilateral in presentation and features a high risk of recurrence. Combined treatment with antiviral and anti-inflammatory drugs are usually required over the long term. Topical ciclosporin can be useful as a corticosteroid-sparing treatment.

  • Cornea
  • Infection
  • Inflammation

Data availability statement

Data are available on reasonable request.

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Data availability statement

Data are available on reasonable request.

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  • Contributors DG, AG, PNK and AR performed data collection. DG, AG, GA and PNK wrote the manuscript with input from all authors. All authors contributed to preparation of the manuscript. DG, IC, ML and EG provided the concept and design, intellectual content. DG is the guarantor.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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