Background/Aims Retinal capillary non-perfusion (NP) and neovascularisation (NV) are two of the most important angiographic changes in diabetic retinopathy (DR). This study investigated the feasibility of using deep learning (DL) models to automatically segment NP and NV on ultra-widefield fluorescein angiography (UWFA) images from patients with DR.

Methods Retrospective cross-sectional chart review study. In total, 951 UWFA images were collected from patients with severe non-proliferative DR (NPDR) or proliferative DR (PDR). Each image was segmented and labelled for NP, NV, disc, background and outside areas. Using the labelled images, DL models were trained and validated (80%) using convolutional neural networks (CNNs) for automated segmentation and tested (20%) on test sets. Accuracy of each model and each label were assessed.

Results The best accuracy from CNN models for each label was 0.8208, 0.8338, 0.9801, 0.9253 and 0.9766 for NP, NV, disc, background and outside areas, respectively. The best Intersection over Union for each label was 0.6806, 0.5675, 0.7107, 0.8551 and 0.924 and mean mean boundary F1 score (BF score) was 0.6702, 0.8742, 0.9092, 0.8103 and 0.9006, respectively.

Conclusions DL models can detect NV and NP as well as disc and outer margins on UWFA with good performance. This automated segmentation of important UWFA features will aid physicians in DR clinics and in overcoming grader subjectivity.