Article Text

Download PDFPDF

At a glance
  1. Frank Larkin, Editor in Chief
  1. Moorfields Eye Hospital NHS Foundation Trust, London, UK
  1. Correspondence to Dr Frank Larkin, Moorfields Eye Hospital, London, UK; f.larkin{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Risk factors for corneal ulcers: a population-based matched case-control study in Nepal (see page 1771)

This population-based matched case-control study in Nepal evaluated risk factors for corneal ulcer. We found that ocular injury, manual labour, and lower education were associated with the development of corneal ulceration in this setting.

Comparison of mini-simple limbal epithelial transplantation and conjunctival–limbal autograft for the treatment of primary pterygium: a randomised controlled trial (see page 1776)

The findings of this double-masked parallel randomised controlled trial comparing mini-simple limbal epithelial transplantation and conjunctival-limbal autograft for the treatment of primary pterygium showed a higher incidence of recurrence in the Mini-Simple Limbal Epithelial Transplantation trial arm.

Immediate sequential bilateral cataract surgery: 13-year real life report of 56 700 cataract operations (see page 1782)

No cases of endophthalmitis occurred in 56 7000 cataract operations in 43255 patients, of whom 31% underwent sequential bilateral cataract surgery (ISBCS). The proportion of ISBCS increased from 4.2% in 2008 to 46% in 2020.

Avoidable childhood blindness in a high-income country: findings from the British childhood visual impairment and blindness study 2 (see page 1787)

In the UK, more than two-thirds of cases of childhood visual impairment are due to disorders for which there is no preventive or therapeutic intervention. There is considerable need for new prevention and treatment approaches.

Modelling ready-made spectacle coverage for children and adults using a large global database (see page 1793)

When applying published prescribing guidelines to a global ophthalmic dataset, it is shown that the different types of ready-made spectacles had limited coverage in child and adult populations, mainly due to astigmatism.

Prevalence of myopia and uncorrected myopia among 721 032 schoolchildren in a citywide vision screening in southern China: the Shantou myopia study (see page 1798)

In this citywide overall survey with 721,032 schoolchildren in Shantou City in southern China, 51.8% had myopia, and 60.0% of the myopic schoolchildren were without any correction, revealing the urgent and severe extent of myopia prevalence and uncorrected myopia in schoolchildren.

Effect of spectacle lenses with aspherical lenslets on choroidal thickness in myopic children: a 2-year randomised clinical trial (see page 1806)

Wearing spectacle lenses with aspherical lens lets reduced or abolished the choroidal thickness decrease associated with myopia progression in children. The higher the asphericity, the stronger the effect.

Effect of atropine, orthokeratology, and combined treatments for myopia control: a 2-year stratified randomised clinical trial (see page 1812)

Atropine combined orthokeratology treatment can improve the efficacy of myopia control compared with monotherapy. Age effect influence the management of myopia. Younger children might benefit more from orthokeratology.

Risk factors associated with abandonment of care in retinoblastoma: analysis of 692 patients from 10 countries (see page 1818)

Based on multinational data, risk factors for the high rates of care abandonment in retinoblastoma include country of residence, advanced disease, and female sex.

Long-term surgical outcomes of Aurolab aqueous drainage implant in pediatric eyes with primary congenital glaucoma versus aphakic glaucoma (see page 1823)

The Aurolab aqueous drainage implant provided long-term intraocular pressure reduction in eyes with primary congenital glaucoma and aphakic glaucoma, with a trend toward higher rates of surgical failure and tube related complications in primary congenital glaucoma.

Association of macular vessel density and ganglion cell complex thickness with central visual field progression in glaucoma (see page 1828)

Lower macular vessel density (VD) and ganglion cell complex thickness (GCC) were both associated with faster past 10–2 CVF worsening. A lower macular VD was more strongly associated with increased odds of past CVF progression event as compared with lower GCC.

Electroretinographic findings in retinal vasculitis (see page 1834)

Retinal vasculitis is generally not associated with significantly poor ffERG responses. The severity of retinal vasculitis was correlated with cone-generated ffERG responses. Retinal vasculitis associated with systemic disease tend to have reduced ffERG responses.

Two-year recall for people with no diabetic retinopathy: a multiethnic population-based retrospective cohort study using real-world data to quantify the effect (see page 1839)

Introduction of biennial diabetic eye screening among people living with diabetes with no diabetic retinopathy on two annual screening appointments could accentuate sociodemographic differences in diabetes related sight loss, especially among younger and non-white populations.

Formal registration of visual impairment in people with diabetic retinopathy significantly underestimates the scale of the problem: a retrospective cohort study at a tertiary care eye hospital service in the United Kingdom (see page 1846)

Visual impairment in patients with diabetic retinopathy can be underestimated by more than 80% when statistics are based on certifications of visual impairment alone.

Automatic interpretation and clinical evaluation for fundus fluorescein angiography images of diabetic retinopathy patients by deep learning (see page 1852)

A multi-task deep learning system was successfully developed for standardised clinical evaluation and lesion classification of fundus fluorescein angiography images of diabetic retinopathy patients and could be applied in clinical practice.

Automated segmentation of ultra-widefield fluorescein angiography of diabetic retinopathy using deep learning (see page 1859)

The importance of ultra-widefield fluorescein angiography (UWFA) in diabetic retinopathy (DR) is increasingly recognised. This study demonstrates that deep learning models can automatically detect nonperfusion and neovascularization on UWFA images from DR eyes.

Macular thickness and its associated factors in a Chinese rural adult population: the Handan eye study (see page 1864)

This study described the normal macular thickness and its associated factors. Age and sex were significantly related to retina thickness in different sectors, and all risk factors need to be considered in clinical diagnosis.

Prevalence and risk-factors for age-related macular degeneration in a population-based cohort study of older adults in Northern Ireland using multi-modal imaging: NICOLA Study (see page 1873)

Prevalence and Risk factors for age-related macular degeneration using multi modal retinal imaging provides additional information beyond colour photography alone particularly for early AMD features. New AMD severity classification systems are urgently needed.

Association of lipid-lowering drugs and anti-diabetic drugs with age-related macular degeneration: a meta-analysis in Europeans (see page 1880)

Systemic use of lipid-lowering drugs and antidiabetic drug is associated with lower prevalence of AMD across multiple European cohorts.

Characterising collateral vessels in eyes with branch retinal vein occlusions using widefield swept-source optical coherence tomography angiography (see page 1887)

This study uses widefield optical coherence tomography angiography to show that many collateral vessels that form after branch retinal vein occlusions lie outside the macula, and that their morphology varies with retinal location.

Impact of adalimumab in patients with active non-infectious intermediate, posterior, and panuveitis in real-life clinical practice: HOPE study (see page 1892)

The HOPE study presents data on real-life effectiveness of adalimumab in patients with active non-infectious intermediate, posterior, and panuveitis. Additionally, it demonstrates improved quality of life and reduction of economic burden in these individuals.

Pupillotonia after endolaser retinopexy during vitrectomy for retinal detachment: a prospective cohort study comparing circumferential and focal retinopexy (see page 1900)

Endolaser during vitrectomy for rhegmatogenous retinal detachment induced tonic pupil postoperatively. Pupillotonia decreased over time, but was detectable 6 months after surgery. Extensive treatment with 360° endolaser retinopexy induced more pupillotonia than focal laser.

Association of hyperopia with incident clinically significant depression: epidemiologic and genetic evidence in the middle-aged and older population (see page 1907)

This study found hyperopia was significantly associated with an increased risk of depression, inferring hyperopia could be a modifiable risk factor for depression. The association was not regulated by genetic predisposition to hyperopia.

Visual outcome and ocular complications in patients with lacrimal gland carcinoma after eye-sparing surgery and adjuvant radiation therapy (see page 1914)

The visual prognosis is reasonably good after eye-sparing surgery and adjuvant radiotherapy in lacrimal gland carcinoma patients; however, significant ocular complications occur and patients with tumours crossing the orbital midline have a higher risk of severe vision loss.

Treatment outcomes and their determinants of immunoglobulin G4-related ophthalmic disease- a territory-wide cohort study (see page 1920)

60% of IgG4-ROD patients required long-term corticosteroids, including those with Mikulicz syndrome and elevated serum IgG4. Patients who did not require medications were associated with debulking surgeries, discrete orbital lesions, normal serum IgG4, and no Mikulicz syndrome.

Real-world clinical and molecular management of 50 prospective patients with microphthalmia, anophthalmia and/or ocular coloboma (see page 1925)

Clinical management of 50 prospective microphthalmia, anophthalmia coloboma (MAC) patients found additional ocular features in 44% and systemic manifestations in 34%, with 28% of families receiving genetic diagnosis. This study aims to guide multidisciplinary care and genetic counselling.

Heteromeric formation with βA3 protects the low thermal stability of βB1-L116P (see page 1936)

L116P mutation markedly decreased the thermal stability of βB1 crystallin and aggregated with elevating protein concentrations. The heteromeric formation with βA3 would protect the low thermal stability of βB1-L116P. This enhances our understanding of the mechanism of βB1 crystallin-related congenital cataracts.

Ethics statements

Patient consent for publication

Ethics approval

Not applicable.


  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.

Linked Articles