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  1. Frank Larkin, Editor in Chief
  1. Moorfields Eye Hospital, London, UK
  1. Correspondence to Frank Larkin, Moorfields Eye Hospital, London, UK; f.larkin{at}

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Ocular morbidity in Marfan syndrome: a nationwide epidemiological study (see page 1051)

This nationwide epidemiological study of ocular morbidity in Marfan syndrome demonstrates a profound burden, compared to controls, especially concerning disorders of lens, retinal detachment, and glaucoma, which translates into significantly increased ophthalmic surgery and medication.

Real-world visual outcomes of cataract surgery based on population-based studies: a systematic review (see page 1056)

There is a lack of population-based data on post-cataract surgery visual acuity outcomes in many countries. Existing evidence demonstrated significant inequality in the visual outcomes and principal causes of visual impairment after cataract surgery among different countries, and even within the same country.

Evaluation of the Nallasamy formula: a stacking ensemble machine learning method for refraction prediction in cataract surgery (see page 1066)

Nallasamy formula, a novel machine learning based IOL power calculation formula developed based on a dataset of 6893 eyes, achieved statistically significantly better prediction accuracy than seven IOL formulas including Barrett Universal II.

Predictors of long-term intraocular pressure control after lens extraction in primary angle closure glaucoma: results from the EAGLE trial (see page 1072)

Lens extraction was>10-times likelier than laser iridotomy to control IOP without drops in PAC/PACG. Chinese ethnicity, baseline IOP, and drop-use at baseline were the strongest predictors for success.

Development and validation of the 40-item Glaucoma Visual Functioning Questionnaire (see page 1086)

The newly designed 40-item Glaucoma Visual Functioning Questionnaire has sufficient validity and reliability to support its use.

Clinical outcomes of penetrating canaloplasty in patients with traumatic angle recession glaucoma: a prospective interventional case series (see page 1092)

We report a prospective case series that demonstrates the safety and efficacy of a new surgical procedure known as penetrating canaloplasty in the treatment of angle recession glaucoma with one year of follow-up.

Telemetric non-contact intraocular pressure monitoring with an implanted sensor in patients with glaucoma: long-term safety report and monitoring data (see page 1098)

The long-term use of telemetric intraocular pressure sensors is reliable and safe and has high patient adherence. This method can improve the quality and effectiveness of glaucoma treatment.

One-year surgical outcomes of the PreserFlo MicroShunt in glaucoma: a multicentre analysis (see page 1104)

Real-world multicentre experience of the PreserFlo MicroShunt with Mitomycin-C 0.4 mg/mL indicates an overall success rate of 68.3% at 1 year, 37% reduction in intraocular pressures, 79% reduction in anti-glaucoma medications and a good safety profile.

Background polygenic risk modulates the association between glaucoma and cardiopulmonary diseases and measures: an analysis from the UK Biobank (see page 1112)

Stratifying by primary open angle glaucoma polygenic risk score, glaucoma was associated with several cardiopulmonary diseases and measures, with greater magnitudes of association among those who developed glaucoma despite low genetic risk.

Changes in glaucoma management following visual field testing and optical coherence tomography (see page 1119)

A change in management occurred following approximately 5% of outpatient glaucoma encounters and was more likely to follow an investigative test measuring optic nerve structure or function vs no such testing.

Validation of DIGIROP models and decision support tool for prediction of treatment for retinopathy of prematurity on a contemporary Swedish cohort (see page 1132)

The specificity of the DIGIROP decision support tool in this validation study corresponded to that obtained in the development study. This tool might make ROP screening more efficient in Sweden when used with the infants’ medical/clinical status.

Quantitative contrast sensitivity test to assess visual function in central serous chorioretinopathy (see page 1139)

Measured with the quantitative contrast sensitivity function (qCSF) device, contrast sensitivity is significantly reduced in CSCR and strongly correlates with patient reported outcomes. Contrast reductions at various spatial frequencies are associated with distinct structural biomarkers.

Disease-specific assessment of vision impairment in low luminance in age-related macular degeneration – a MACUSTAR study report (see page 1144)

Results from the MACUSTAR study support that the vision impairment in low luminance (VILL) questionnaire is a psychometrically sound, reliable and valid patient-reported outcome instrument designed for use in age-related macular degeneration.

NDP-related retinopathies: clinical phenotype of female carriers (see page 1151)

Although Norrin cysteine knot growth factor (NDP)-related retinopathy is an X-linked recessive disorder, most of the female carriers of NDP-related retinopathy exhibited clinical features of familial exudative vitreoretinopathy (FEVR).

Retinal nerve fibre layer thickness measured with SD-OCT in a population-based study: the Handan Eye study (see page 1156)

The application of a standard European RNFL database to evaluate Chinese population is inaccurate. There are many factors affecting the measurement of RNFL which cannot be ignored in disease diagnosis.

Change of peripapillary retinal nerve fibre layer and choroidal thickness during 4-year myopic progress: Boramae Myopia Cohort Study Report 4 (see page 1165)

Thickness of the peripapillary retinal nerve fibre layer (RNFL) and choroid, as well as the locations of the RNFL peaks, remained stable during 4 year myopic progression in childhood.

Quantitative evaluation of retinal and choroidal vascularity and retrobulbar blood flow in patients with myopic anisometropia by CDI and OCTA (see page 1172)

We simultaneously investigated retinal microvascular density, choroidal vascularity, and retrobulbar blood flow in a single cohort of adult myopic anisomyopes. All parameters were lower in more myopic eyes, and LA and ChT were independent risk factors affecting both AL and SE

Prevalence and causes of visual impairment and blindness in Lao People’s Democratic Republic: the Vientiane Eye Study (see page 1178)

The population-weighted prevalence of bilateral blindness and visual impairment in adults aged 40 years or older living in Vientiane Province was 1.4% and 22.4%, respectively. Cataract was the leading cause of blindness.

Barriers to uptake of referral eye care services among the elderly in residential care: the Hyderabad Ocular Morbidity in Elderly Study (HOMES) (see page 1184)

Despite provision of free services, the uptake of eye care services remains low among the elderly in residential care in India. Lack of perceived need for services is the leading reason for poor uptake of services.

Incidence, causes and risk factors of vision loss in rural southern China: six-year follow-up of the Yangxi Eye Study (see page 1190)

We report the six-year incidence, causes, and risk factors for vision loss among elderly adults in rural southern China. Substantial work is still required to reduce avoidable vision loss.

Utilisation of composite endpoint outcome to assess efficacy of tocilizumab for non-infectious uveitis in the STOP-Uveitis Study (see page 1197)

Due to diverse presentations of uveitis, a robust composite scoring system taking multiple factors into account, as proposed in this study, may provide significant advantage over a single parameter to assess efficacy in clinical studies.

Abnormal foveal morphology in carriers of oculocutaneous albinism (see page 1202)

In this cross-sectional study, oculocutaneous albinism (OCA) carriers demonstrate low grades of foveal hypoplasia on optical coherence tomography. The presence of foveal hypoplasia suggests arrested retinal development in OCA carriers.

Human intrinsic choroidal neurons do not alter the expression of intrinsic markers in response to pressure (see page 1209)

Choroids were pressurised (1 hour/4 hours) and specific responses of intrinsic choroidal neurons analysed (mRNA for VIP/UCN/NOS1/UCH-L1). A significant molecular response was lacking in any experimental condition, while NOS1 and VIP were higher in temporal hemi-choroid examinations.

Association of SIX1-SIX6 polymorphisms with peripapillary retinal nerve fibre layer thickness in children (see page 1216)

This study revealed the associations of SIX1-SIX6 rs33912345 and rs10483727 with peripapillary retinal nerve fibre layer thickness at temporal-inferior in children, indicating a role of this locus in childhood neural retina development with spatial variation.

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  • Contributors n/a.

  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.

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