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Low-dose atropine 0.01% for the treatment of childhood myopia: a pan-India multicentric retrospective study
  1. Rohit Saxena1,
  2. Vinay Gupta1,
  3. Rebika Dhiman1,
  4. Elizabeth Joseph2,
  5. Sumita Agarkar3,
  6. R Neena4,
  7. Damaris Magdalene5,
  8. Jitendra Jethani6,
  9. Sandra C Ganesh7,
  10. Minal Patil8,
  11. Pooja Gogri9,
  12. Shailesh Gadaginamath10,
  13. Pradhnya Sen11,
  14. Jaspreet Sukhija12,
  15. Deepak Mishra13,
  16. Jyoti H Matalia14,
  17. Anupam Sahu15,
  18. Smita Kapoor16,
  19. Shruti Nishanth17,
  20. Shweta Chaurasia12,
  21. Neelam Pawar18,19,
  22. Nilutparna Deori5,
  23. Viswanathan Sivaraman3,
  24. Anamika Bordoloi5,
  25. Shailja Tibrewal20,
  26. Davinder Singh1,
  27. Priyanka Prasad1,
  28. Swati Phuljhele1,
  29. Namrata Sharma1
  1. 1 Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
  2. 2 Ophthalmology, Little Flower Hospital, Angamaly, Ernakulam, Kerala, India
  3. 3 Department of Pediatric Ophthalmology and Strabismus, Sankara Nethralaya, Chennai, Tamil Nadu, India
  4. 4 Giridhar Eye Institute, Kochi, Kerala, India
  5. 5 Sri Sankaradeva Nethralaya, Guwahati, Assam, India
  6. 6 Pediatric Ophthalmology, Baroda Children Eyecare and Squint Clinic, Vadodara, Gujarat, India
  7. 7 Paediatric Ophthalmology and Strabismus, Aravind Eye Care System, Coimbatore, Tamil Nadu, India
  8. 8 Drishti Eye Institute, Dehardun, Uttrakahand, India
  9. 9 Jyotirmay Eye Clinic, Thane, Maharashtra, India
  10. 10 Ophthalmology, Shekhar Hospital, Bangalore, Karnataka, India
  11. 11 Department of Paediatric Ophthalmology and Strabismus, Shri Sadguru Seva Sangh Trust Chitrakoot Centre, Chitrakoot, Madhya Pradesh, India
  12. 12 Department of Ophthalmology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
  13. 13 Regional institute of Ophthalmology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
  14. 14 Pediatric Ophthalmology and strabismus, Narayana Nethralaya, Bangalore, India
  15. 15 Pediatric Ophthalmology, MGM Eye Institute, Raipur, Chhattisgarh, India
  16. 16 Pediatric Ophthalmology and Strabismus, Sankara Eye Hospital Coimbatore, Coimbatore, India
  17. 17 Ophthalmology, M N Eye Hospital, Chennai, Tamil Nadu, India
  18. 18 Pediatric and Squint, Aravind Eye Hospital, Tirunelveli, Tamil Nadu, India
  19. 19 Kellogg Eye Centre, University of Michigan, Ann Arbor, Michigan, USA
  20. 20 Pediatric Ophthalmology and Strabismus, Shroff Charity Eye Hospital, New Delhi, Delhi, India
  1. Correspondence to Dr Rohit Saxena, Ophthalmology, Dr Rajendra Prasad Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi 110029, India; rohitsaxena80{at}


Objective The objective of this study was to assess the efficacy of low-dose atropine 0.01% in controlling myopia progression among Indian children over a 2-year period.

Methods This retrospective study, conducted across 20 centres in India, monitored the progression of myopia over 2 years after initiating treatment with 0.01% atropine eye drops. This included children between 6 and 14 years with baseline myopia ranging from −0.5 D to −6 D, astigmatism≤−1.5 D, anisometropia ≤ −1 D and documented myopia progression of ≥0.5 D in the year prior to starting atropine. Subjects with any other ocular pathologies were excluded.

Results A total of 732 children were included in the data analysis. The mean age of the subjects was 9.3±2.7 years. The mean myopia progression at baseline (1 year before starting atropine) was −0.75±0.31 D. The rate of myopia progression was higher in younger subjects and those with higher baseline myopic error. After initiating atropine, myopia progression significantly decreased to −0.27±0.14 D at the end of the first year and −0.24±0.15 D at the end of the second year (p<0.001). Younger children (p<0.001) and higher baseline myopia (p<0.001) was associated with greater myopia progression and poor treatment response (p<0.001 for both).

Conclusion Low-dose atropine (0.01%) effectively reduces myopia progression over 2 years in Indian children.

  • Treatment Medical

Data availability statement

Data are available upon reasonable request.

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Data availability statement

Data are available upon reasonable request.

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  • Contributors Overall responsibility: RS. Study supervision: RS, RD, SPA and NS. Conception and design: RS, VG and NS. Data collection: RS, VG, RD, EJ, SA, RN, DM, JJ, SCG, MP, PG, SG, PS, JS, DM, JHM, AS, SK, SN, SC, NP, ND, VS, AB, ST, DS, PP and SPA. Analysis and interpretation: RS, VG, DS, RD, SPA and NS. Manuscript draft and review: RS, VG, RD, EJ, SA, RN, DM, JJ, SCG, MP, PG, SG, PS, JS, DM, JHM, AS, SK, SN, SC, NP, ND, VS, AB, ST, DS, PP, SPA and NS. Administrative, technical or material support: RS, RD, EJ, SA, RN, DM, JJ, SCG, MP, PG, SG, PS, JS, DM, JHM, AS, SK, SN, NP, ST, SPA, NS. Guarantor: RS.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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