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  1. Frank Larkin, Editor in Chief
  1. Cornea and External Disease Department, Moorfields Eye Hospital NHS Foundation Trust, London, UK
  1. Correspondence to Frank Larkin, Moorfields Eye Hospital, London, UK; f.larkin{at}

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Characterisation of ectasia after penetrating keratoplasty in keratoconus eyes using anterior-segment optical coherence tomography (see page 506)

Optical coherence tomography can be used to image corneal ectasia which occurs late following penetrating keratoplasty. Corneas with late post-keratoplasty ectasia have a deeper anterior chamber, steeper graft-host interface angle, and lower thickness at the interface

Crystalline lens nuclear age prediction as a new biomarker of nucleus degeneration (see page 513)

A deep learning algorithm was developed to predict nuclear age, which provides insight into the premature ageing of the lens nucleus. Findings also suggest that nuclear age could serve as an indirect marker for nuclear cataract.

Adduction induces large optic nerve head deformations in subjects with normal tension glaucoma (see page 522)

Adduction movement was found to induce large strains in the optic nerve head. Higher strain, especially at the lamina cribrosa, associated with adduction was found in eyes with normal tension glaucoma than with high tension glaucoma.

Fundus topographical distribution patterns of ocular toxoplasmosis (see page 530)

Topographic mapping of 984 toxoplasma lesions showed that all primary lesions had maximum overlap at a point 278 microns inferotemporal to foveola. Recurrent lesions were found to be significantly smaller in size.

Deep learning automated quantification of longitudinal OCT scans demonstrates reduced RPE loss rate, preservation of intact macular area and predictive value of isolated photoreceptor degeneration in geographic atrophy patients receiving C3 inhibition treatment (see page 536)

Intravitreal complement inhibitor pegcetacoplan demonstrates a statistically significant association with slower progression of geographic atrophy on OCT using an auto-segmentation machine learning- based platform. This analytical method is a novel clinical and research outcome measures.

Distribution and determinants of choroidal vascularity index in healthy eyes from deep-learning choroidal analysis: a population-based SS-OCT study (see page 546)

This first AI- and SS-OCT based study profiled the choroidal vascularity index in Chinese adults and revealed the essential role of ageing and axial elongation in population-based samples.

Outcomes following repair of early- versus delayed-onset rhegmatogenous retinal detachments after acute posterior vitreous detachment (see page 552)

Eyes developing retinal detachments over 6 weeks after diagnosis of posterior vitreous detachment had better visual acuity at time of retinal detachment and faster postoperative recovery compared with eyes with retinal detachment at initial presentation.

Deep phenotyping of PROM1-associated retinal degeneration (see page 558)

This is the first in-depth analysis to include adaptive optics scanning laser ophthalmoscopy in patients with PROM1-associated retinal degeneration. The evidence of residual cones in both autosomal dominant and recessive disease indicates a potential opportunity for therapeutic intervention.

Intraocular medulloepithelioma clinical features and management of 11 cases (see page 566)

Initial mismanagement of ciliary body medulloepithelioma is common. UBM can provide useful diagnostic clues and help with differential diagnosis. There is evidence that intra-arterial chemotherapy for medulloepithelioma appears to provide control in selected patients.

Risk factors for cataract in retinoblastoma management (see page 571)

Among the eye-preserving treatments of retinoblastoma, intra-arterial and intravitreal chemotherapy are the most likely to induce cataract. Higher melphalan dose is considered to be an important risk factor for cataract formation, reflecting the toxicity of melphalan.

Obesity paradox in uveal melanoma: high body mass index is associated with low metastatic risk (see page 578)

In this nationwide Swedish study, obesity was associated with a lower risk for developing metastases and dying from uveal melanoma. Similarly, patients with elevated serum levels of leptin at diagnosis had significantly longer metastasis-free survival.

Low dose atropine 0.01% for the treatment of childhood myopia: a pan-India multicentric retrospective study (see page 588)

Atropine 0.01% drops effectively curbed myopia progression in Indian children, providing steady benefits for two years. Higher myopia and younger age were linked to heightened progression, showing weaker response to atropine 0.01%.

Prevalence and associated factors of myopia in children and adolescents in Russia: the ural children eye study (see page 593)

Prevalence of any myopia (65.6%) and high myopia (4.6%) was higher in schoolchildren from Russia (aged 17+years) than in adult Russian populations, and was lower than in East Asian schoolchildren.

The association of retinal optical coherence tomography metrics and polygenic risk scores with cognitive function and future cognitive decline (see page 599)

Retinal layer thickness changes are associated with the genetic risk for Alzheimer’s and Parkinson’s disease. Prediction of future cognitive decline was significantly improved with the addition of polygenic risk scores and retinal measurements.

Papillary vitreous detachment as a possible accomplice in non-arteritic anterior ischaemic optic neuropathy (see page 607)

Papillary vitreous detachment may contribute to the pathogenesis of non-arteritic anterior ischaemic optic neuropathy.

Lower eyelid lengthening in facial nerve palsy: when is a periosteal flap required? (see page 613)

Patients with facial nerve palsy often require horizontal eyelid lengthening (e.g. with a lateral periosteal flap) following medial canthal tendon plication. Surgeons managing such patients should take care to identify inadvertent early shortening.

Lacrimal gland activity in lacrimal drainage obstruction: exploring the potential crosstalk between the tear secretion and outflow (see page 621)

Secretory activity of the lacrimal gland reduces significantly in eyes with unilateral lacrimal outflow obstruction compared with the contralateral side.

Determinants of non-attendance at face-to-face and telemedicine ophthalmic consultations (see page 625)

In this retrospective cohort of 86 049 patients, teleophthalmic non-attendance was highest among men, those living in areas of greater deprivation and those not self-reporting their ethnicity. The disparities in telemedicine engagement among certain sociodemographic groups risk exacerbating pre-existing inequalities.

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  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.